C E Lesnick

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The detection of abnormal plasma cells (PCs) is a fundamental element in diagnosing plasma cell proliferative disorders (PCPDs) such as multiple myeloma. Flow cytometry (FC) is routinely employed for this purpose; by this method, neoplastic PCs are identified either by restricted patterns of cytoplasmic immunoglobulin (cy-Ig) light chain expression or by(More)
Groups of newborn piglets were vaccinated orally with a modified live transmissible gastroenteritis (TGE) virus vaccine at 3 days and 13 days of age, and treated with the synthetic interferon (IFN) inducer polyinosinic:polycytidylic acid (poly ICLC) at 2, 3 or 4 days of age. Control groups consisted of piglets which were vaccinated but not treated with poly(More)
The aim of this study was to produce sustained activation of natural killer (NK) cells in newborn piglets by interferon (IFN) induction with polyinosinic:polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose [poly(ICLC)]. When a second dose of poly(ICLC) was given 24 or 48 h after the first dose, the piglets were found to be(More)
Natural killer (NK) cell activity in the peripheral blood lymphocytes (PBL) of newborn piglets, normally negligible, was stimulated by in vitro treatment with porcine type I interferon (IFN), and the NK activity of PBL from weaned piglets was augmented by the same treatment. Binding of the PBL to the PK-15 targets used in the single cell cytotoxicity assay(More)
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