Much is known about the potential consequences of prenatal alcohol exposure through data developed in animals and man. However, little attempt has been made to compare the human and animal literature with respect to qualitative and quantitative similarities and differences. To this end, a comparison was made between the effects reported in humans following… (More)
The effect of prenatal alcohol exposure on nipple attachment behavior was studied at a number of ages in rat pups whose mothers consumed liquid diets containing 35% or 0% ethanol-derived calories (EDC) or standard lab chow during pregnancy. In the first experiment, nondeprived pups were tested in groups of three (one from each of the prenatal treatment… (More)
Amobarbital sodium (17.5 mg/kg) produced equivalent reductions in negative contrast when injected for the first time on either day 1 or 2 following a shift from 32% to 4% sucrose. These results differed from those obtained in earlier studies with chlordiazepoxide.
PURPOSE These investigations were undertaken to compare and contrast the roles of phosducin and phosducin-like protein in the retina. METHODS Phosducin and phosducin-like protein were compared in an in vitro assay measuring their inhibition of transducin binding to light-activated rhodopsin. The two proteins were localized within the retina by immunoblot… (More)
The present study examined the effects of physostigmine, a cholinesterase inhibitor, on activity in young rats whose mothers consumed isocaloric liquid diets containing 35% or 0% ethanol-derived calories on days 6-20 of pregnancy. A pair-feeding procedure was utilized and an ad libitum lab chow group was included. Physostigmine was administered to… (More)
Long-Evans, hooded rats were intubated with one of four dose combinations of pentazocine and tripelennamine on Days 7-20 of pregnancy: 0:0 (mg/kg pentazocine:tripelennamine), 20:10, 40:0, or 40:20. An additional group had free access to lab chow and water throughout pregnancy. At birth, reduced body weights were evident in all drug-treated offspring. Growth… (More)
Parallels between the behavioral profiles of rats exposed to alcohol prenatally and those with hippocampal damage suggest that hippocampal dysfunction may underlie some of the behavioral abnormalities resulting from prenatal alcohol exposure. Because of possible hippocampal involvement in the acquisition of a delayed conditioned taste aversion, this task… (More)
The effects of prenatal alcohol exposure on the development of a conditioned taste aversion were examined in preweanling rat pups. Mothers of these pups were fed isocaloric liquid diets containing either 35 or 0% ethanol-derived calories (EDC) from gestation days 6 through 20. A pair-feeding procedure was employed, and an ad lib lab chow control group was… (More)