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Cutaneous adverse events induced by epidermal growth factor receptor (EGFR) inhibitors can hamper the patients' quality of life. The aim of our work was to draft an algorithm for the optimised management of this skin toxicity. This algorithm was built in three steps under the responsibility of a steering committee. Step I: a systematic literature analysis(More)
The efficacy and toxicity of the new anthracycline, 4'-0-tetrahydropyranyl doxorubicin (THP) (50 mg/m2 intravenous [IV] bolus) in association with cisplatin (100 mg/m2 IV as a 4-hour infusion) was assessed in 31 patients with advanced ovarian carcinoma. Twenty-eight patients were assessable for toxicity among whom 25 were assessable for response(More)
OBJECTIVE The purpose of this study was to determine the clinical and prognostic features of leukemias and preleukemic states, whatever the mode of development, observed in patients after treatment of breast cancer. PATIENTS AND METHODS A retrospective multicentric analysis was made of 121 patients treated for breast cancer and who later developed(More)
4104 Background: Neoadjuvant chemoradiotherapy (CRT) with tegafur-uracil (UFT) plus leucovorin (LV) has shown promising results in patients with rectal adenocarcinoma (RAC). We therefore conducted a phase III trial to compare neoadjuvant CRT with UFT/LV versus radiotherapy (RT) alone. METHODS One hundred seventy seven pts with RAC stage T3 (T4 if anal(More)
La présence d’une maladie résiduelle infracentrimétrique après chirurgie de debulking des cancers ovariens avancés est le facteur pronostique le plus important. La chirurgie d’intervalle après trois à six cycles de chimiothérapie augmente-t-elle le taux de résection infracentimétrique ? Le but de cette étude est de comparer le taux de résection(More)
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