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BACKGROUND Despite the widespread use of over-the-counter H2-receptor antagonists little is known about their duration of action on human gastric acid secretion. There are studies reporting inhibitory effects for up to 9 h post-dose but few data beyond this period. METHODS Profiles of 20-h intragastric acidity were measured simultaneously in 24 healthy(More)
BACKGROUND H2-receptor antagonists are becoming widely available as over-the-counter medications for the treatment of heartburn and excess gastric acidity. AIM To determine the effects of single low doses of ranitidine on intragastric acidity. METHODS Intragastric pH was measured for 9 h after lunch in five studies involving 24 healthy male volunteers.(More)
Despite relatively widespread use of various forms of patient controlled analgesia (PCA), there remain conflicting results in the literature as to the efficacy of PCA. This study was conducted to assess the efficacy and postoperative outcomes of intravenous PCA compared to intramuscular (IM) injections in 73 patients who received major abdominal surgery.(More)
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