C.-C. Li

Learn More
We propose, in this paper, models of schistosomiasis that incorporate several realistic features including two human habitats, migration between these, negative binomial distribution of sehistosomes within human hosts, disease-induced mortality in both human and snail hosts, and others. The qualitative and quantitative mathematical properties are analyzed.(More)
In this study, we have developed a multiscale systems model of interleukin (IL)-6-mediated immune regulation in Crohn's disease, by integrating intracellular signaling with organ-level dynamics of pharmacological markers underlying the disease. This model was linked to a general pharmacokinetic model for therapeutic monoclonal antibodies and used to(More)
Both gemcitabine and weekly 24-h infusion of high-dose 5-fluorouracil/leucovorin (HDFL) have shown promising antitumour activity for patients with locally advanced or metastatic carcinoma of the biliary tract (CBT). From April 1999 through December 2002, 30 patients with inoperable CBT were treated with gemcitabine 800 mg m(-2), intravenous infusion for 30(More)
Cancer immunotherapy (CIT) initiates or enhances the host immune response against cancer. Following decades of development, patients with previously few therapeutic options may now benefit from CIT. Although the quantitative clinical pharmacology (qCP) of previous classes of anticancer drugs has matured during this time, application to CIT may not be(More)
  • A Alshekhlee, C-C Li, S-Y Chuang, N Vora, R C Edgell, J M Kitchener +5 others
  • 2011
BACKGROUND Dementia represents a potential challenge when thrombolysis is a treatment option. In this study, we assess the impact of dementia on the rate of intracerebral hemorrhage (ICH) and hospital mortality associated with acute ischemic stroke (AIS) in patients treated with thrombolysis. METHODS A cohort of patients with AIS was identified from the(More)
  • 1