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It remains unclear whether causal, rather than merely correlational, relationships in molecular networks can be inferred in complex biological settings. Here we describe the HPN-DREAM network inference challenge, which focused on learning causal influences in signaling networks. We used phosphoprotein data from cancer cell lines as well as in silico data(More)
Hypoxia-inducible factor (HIF-1) is the key transcription regulator for multiple angiogenic factors and is an appealing target. Ginsenoside-Rg1, a nontoxic saponin isolated from the rhizome of Panax ginseng, exhibits potent proangiogenic activity and has the potential to be developed as a new angiotherapeutic agent. However, the mechanisms by which Rg1(More)
This paper reports the design of a sophisticated wysiwyg L a T E X-like typesetting system Vi e w T E X. Our approach is based on the Model-View-Controller (MVC) user-interface paradigm, as originated from the Smalltalk community. According to the paradigm, the Vi e w T E X system is decomposed into the sub-editor (model) module, the redisplay (view)(More)
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