C. C. Jorgensen

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The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described. A screening hit 1 with low lipophilic efficiency (LipE) was optimized through two key structural modifications: (1) identification of the pyrrolidine amide group for a significant LipE improvement, and (2) insertion(More)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111 ... Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Optimization of Local Object Avoidance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3(More)
The terrain acquisition problem deals with the acquisition of the complete obstacle terrain model by a mobile robot placed in an unexplored terrain. This is a precursory problem to many well-known find-path and related problems which assume the availability of the complete terrain model. In this paper, we present a method for terrain acquisition by a(More)
Navigation planning is one of the most vital aspects of an autonomous mobile robot. The problem of navigation in a completely known obstacle terrain is solved in many cases. Comparatively less number of research results are reported in literature about robot navigation in a completely unknown obstacle terrain. In recent times, this problem is solved by(More)
Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising strategy to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis. Monoacylglycerol acyltransferase 3 (MGAT3) is an integral membrane enzyme that catalyzes the acylation of both monoacylglycerol (MAG) and diacylglycerol (DAG) to generate DAG and TAG,(More)
Cholinergic hypofunction is associated with decreased attention and cognitive deficits in the central nervous system in addition to compromised motor function. Consequently, stimulation of cholinergic neurotransmission is a rational therapeutic approach for the potential treatment of a variety of neurological conditions. High affinity choline uptake (HACU)(More)
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