C. C. Glüer

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Quantitative computed tomography (QCT) has been shown to be a precise and sensitive method for evaluating spinal bone mineral density (BMD) and skeletal response to aging and therapy. Precise and accurate determination of BMD using QCT requires a calibration standard to compensate for and reduce the effects of beam-hardening artifacts and scanner drift. The(More)
Noninvasive measurements of bone mineral density allow the assessment of skeletal integrity, both centrally and peripherally, with high precision and accuracy and with relatively low radiation dose. When estimating skeletal status, it may be important to measure bone mineral density at more than one site to assess differential skeletal responses related to(More)
In response to our publication [1], Wilson and colleagues [2] proposed the adoption of a uniform tcrminology and corresponding abbreviation for Dual X-ray Absorptiometry (DXA). We supported this suggestion [3]. Since then, the number of papers on DXA has increased considerably. Still, different abbreviations (DEXA, DER, DRA, Q D R and DPX) for this(More)
Despite an increasing use of high-resolution peripheral quantitative computed tomography (HR-pQCT) to evaluate bone morphology in vivo, there are reservations about its applicability in patients with osteoporosis and antiresorptive therapy. This study shows that HR-pQCT provides acceptable in vivo accuracy for bone volume fraction (BV/TV) in patients with(More)
The correlations between the failure load of 20 T12 vertebral bodies, their patient-mode high-resolution peripheral quantitative computed tomography (HR-pQCT) indices, and the L1 areal bone mineral density (aBMD) were investigated. For the prediction of the T12 vertebral failure load, the T12 HR-pQCT microarchitectural parameters added significant(More)
The purpose of this study was to describe the normal cross-sectional pattern of spinal bone loss associated with aging in an Italian population and to compare these values to the American normative database. A group of 472 healthy subjects (382 females and 90 males) were recruited for bone mineral density (BMD) assessment by quantitative computed tomography(More)
A concept for quality assurance (QA) in bone densitometry has been developed for clinical multicenter studies. Major elements provided by a coordinating center comprise (1) consulting services and certification of participating centers in the start-up phase of the study, (2) review of scan data acquired on QA standards for cross-calibration and longitudinal(More)
The purpose of this study is to evaluate degenerative factors in a postmenopausal patient group and differentiate the influence on bone mineral density (BMD) measurements by dual-energy X-ray absorptiometry (DXA). The patients and methods included an investigation of 144 postmenopausal women (mean 63.3 years) with PA-DXA of the spine. Degenerative factors(More)
In this study we analyzed the effect of variations in bone area size, baseline soft tissue composition represented by the R-value, and bone region of interest positioning on the precision in vivo of bone mineral density (BMD) and content (BMC) as measured by dual X-ray absorptiometry (DXA). The posterior-anterior (PA) spine, decubitus latcral, and femur(More)
This is part 2 of a core chapter of the forthcoming Report on Bone Densitometry commissioned by the International Commission on Radiation Units (ICRU). It is written with the aim to review definitions of quantities and units used in bone densitometry research and to describe parameters and methods that can be used to compare and standardize densitometric(More)