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Mongolian gerbils were exposed for 12 months to trichloroethylene (TCE) 50 or 150 ppm or perchloroethylene (PCE) 120 ppm. Vermis posterior of cerebellum and hippocampus were used for measurement of high-affinity uptake and release of 3H-gamma-aminobutyric acid (GABA) and 14C-glutamate, as well as for determination of total free tissue amino acids and(More)
Glial S-100 protein, soluble protein, and DNA were quantitatively studied in brains of gerbils chronically exposed to ethanol in a nutritionally complete fluid diet. Eight different brain areas were studied. After exposure to ethanol for 3 months followed by a 4-month post-treatment ethanol-free period, increased amounts of S-100 protein per wet weight were(More)
The exposure of adult Mongolian gerbils to 60 or 320 ppm trichloroethylene (TCE) by continuous inhalation during 3 months, followed by a period of 4 months free of exposure, causes biochemical changes in the hippocampus, the posterior part of cerebellar vermis and in the brain stem, compatible with alterations comprising astroglial hypertrophy and/or(More)
Mongolian gerbils were exposed to dichloromethane for three months by continuous inhalation at 210 ppm. Total free tissue amino acids, glutathione, and phosphoethanolamine were determined in the vermis posterior of the cerebellum and the frontal cerebral cortex. These two brain areas were chosen because humans occupationally exposed to dichloromethane have(More)
Inhalation exposure of adult Mongolian gerbils to 320 ppm of trichloroethylene (TCE) during 8 weeks causes a decrease of soluble proteins per wet weight in frontal cerebral cortex, cerebellar anterior part of the hemispheres and in the posterior part of vermis, as well as in hippocampus, although the levels of S 100, a glial cytoplasmic protein, showed an(More)
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