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The hypothesis of prefrontal dysfunction in psychopathy has been pursued for many years, without convincing results. It is proposed here that this approach in previous studies was far too global. The present investigation was carried out in order to test a more specific hypothesis of orbitofrontal and/or frontal ventromedial deficits in psychopathy.(More)
Two major lines of investigation are currently clarifying the nature of the impairment of working memory associated with normal aging. Cognitive psychology has formulated the problem in terms such as the balance of impairment of encoding, retrieval, storage and/or attention, whereas neuropsychology has formulated the problem in terms such as the balance of(More)
OBJECTIVE Executive functions in activities of daily living (ADL) were investigated in 10 patients with frontal lobe lesions after a mild to severe closed head injury (CHI). METHOD The CHI patients were compared to 12 normal controls with a neuropsychological test battery, a script recitation task and a realistic simulation of complex multitask ADL(More)
With a multiple case report analysis we demonstrate that hypersexuality more often results from right hemisphere (RH) (n=26) than left hemisphere (LH) (n=7) lesions, possibly because of LH release after the RH lesion, and that ictal orgasm more often occurs in patients with right-sided (n=23) than left-sided (n=8) seizure foci, with the symptom probably(More)
This essay reviews research on interhemispheric transfer time derived from simple unimanual reaction time to hemitachistoscopically presented visual stimuli. Part 1 reviews major theoretical themes including (a) the significance of the eccentricity effect on interhemispheric transfer time in the context of proposed underlying neurohistological constraints;(More)
Previously published single case reports of patients with a unilateral lesion were assembled. After the lesion, each of the 244 cases presented at least one of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) symptoms of a manic episode, namely, elated or irritable mood, grandiosity, talkativeness, flight of ideas,(More)
INTRODUCTION A detailed proposal is made to the effect that nonlesional antisocial personality disorder (APD) is, among other things, a dysfunctional hypomoralism and that nonlesional obsessive-compulsive disorder (OCD) is, among other things, a dysfunctional hypermoralism. METHOD To provide an empirical test of this proposal, 25 previously published(More)
Impaired executive function and impulsiveness or intolerance to boredom in adult attention deficit/hyperactivity disorder (ADHD) are thought to compromise performance at work. Several task parameters help people with ADHD to perform better on computerized cognitive tasks, namely reduced response-to-stimulus interval, discriminative feedback, or a format(More)
CONTEXT The staging of Alzheimer disease (AD) dementia could be improved by a neurometabolic analysis using magnetic resonance spectroscopy. OBJECTIVE To examine the correlation between regional cerebral metabolic alterations measured by proton magnetic resonance spectroscopy and neuropsychological dysfunctions in patients with early AD. DESIGN A(More)