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PURPOSE To analyze the cellular and network mechanisms of sustained seizures, we reviewed the literature and present new data on in vitro epileptiform events. We considered single and recurring synchronized population bursts occurring on a time scale from tens of milliseconds to 1 min. METHODS We used intracellular and field potential recordings, together(More)
Epileptic discharges lasting 2-90 s, were studied in vitro in slices from the ventral hippocampus of adult rats, in which inhibition was blocked acutely with bicuculline methiodide (BMI, 5-30 microM) and potassium ([K(+)](o)) raised to 5 mM. These seizure-like events (SLEs) comprised three distinct phases, called here primary, secondary, and tertiary(More)
A single, minute dose of tetanus toxin injected into mammalian cerebral cortex induces a chronic epileptic syndrome. Seizures lasting up to 3 minutes occur spontaneously and intermittently for several weeks to months. The cellular mechanisms of this model have been studied in detail using brain slicesin vitro. Initially the release of the inhibitory(More)
Cartilage differentiation in the upper limb bud of the white mouse (NMRI) begins in the humerus anlage on day 12 + 13 h p.c.; cartilage differentiation in the phalanges begins on day 13 + 3 h p.c. Morphologically, differentiation can be characterized as follows: (1) cell densifications with an increase in contact structures between the cells in the blastema(More)
  • C Borck
  • 1977
The development of the myo-tendinous junction in the upper extremity of mouse embryos of days 15 p.c. to 1 p.p. was studied electron microscopically. In the region of the myo-tendinous junction two cell types can be differentiated (muscle cells, fibroblasts) which undergo characteristic changes during the course of their development: The muscle cells show(More)
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