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BACKGROUND Cystic fibrosis (CF) lung disease manifest by impaired chloride secretion leads to eventual respiratory failure. Candidate genes that may modify CF lung disease severity include alternative chloride channels. The objectives of this study are to identify single nucleotide polymorphisms (SNPs) in the airway epithelial chloride channel, CLC-2, and(More)
BACKGROUND Recent studies indicate that the composition of fine particulate matter [PM <or= 2.5 microm in aerodynamic diameter (PM(2.5))] is associated with increased hospitalizations for cardiovascular and respiratory diseases. The metal composition of PM(2.5) influences allergic and/or inflammatory reactions, and ambient zinc contributes to worsening(More)
Because the lung stem cell field is so new, there remain many unanswered questions that are being addressed regarding the identification, location, and role of exogenous and endogenous stem and progenitor cell populations in growth, regeneration, and repair of the lung. Advancing lung stem cell biology will require multidisciplinary teams and a long term(More)
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