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BACKGROUND Cystic fibrosis (CF) lung disease manifest by impaired chloride secretion leads to eventual respiratory failure. Candidate genes that may modify CF lung disease severity include alternative chloride channels. The objectives of this study are to identify single nucleotide polymorphisms (SNPs) in the airway epithelial chloride channel, CLC-2, and(More)
OBJECTIVE To characterize risks to infants and young children from drugs and biological products that were identified in spontaneous adverse event reports submitted to the US Food and Drug Administration. METHODS Of >500 000 MedWatch adverse event reports received by the Food and Drug Administration from November 1997 through December 2000, we identified(More)
BACKGROUND Recent studies indicate that the composition of fine particulate matter [PM <or= 2.5 microm in aerodynamic diameter (PM(2.5))] is associated with increased hospitalizations for cardiovascular and respiratory diseases. The metal composition of PM(2.5) influences allergic and/or inflammatory reactions, and ambient zinc contributes to worsening(More)
Recognizing the importance of improving lung health through lung disease research, the National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of multidisciplinary experts for the following purpose: (1) to review the current scientific knowledge underlying the basis for treatment of adults and children with pulmonary vascular diseases (PVDs);(More)
Because the lung stem cell field is so new, there remain many unanswered questions that are being addressed regarding the identification, location, and role of exogenous and endogenous stem and progenitor cell populations in growth, regeneration, and repair of the lung. Advancing lung stem cell biology will require multidisciplinary teams and a long term(More)
BACKGROUND General practitioners (GPs) have a central place in the management of asthma, particularly in the context of acute exacerbations. AIM To evaluate the management of asthma exacerbations by GPs, and to investigate the ability of risk factors for near fatal asthma to predict the severity of asthma attacks in the community. DESIGN OF STUDY A(More)
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