C B Tyler

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The effects of phencyclidine on aggressive behavior in mice and the possible mechanism of action for these effects were examined. PCP at a dose of 10.0 mg/kg significantly decreased the number of attacks by resident mice toward intruders. Significant increases in the number of attacks by non-drugged residents toward the intruders who were given high doses(More)
In order to study the inhibitory mechanisms regulating dopamine (DA) synthesis in vivo, the effect of amphetamine in the presence and absence of selective D1 and D2-DA receptor antagonists was examined in various brain regions. In response to amphetamine (3 mg/kg s.c.) administration, DA synthesis in the striatum, but not the nucleus accumbens or the medial(More)
Rats received chronic subcutaneous or intrathecal infusions of either saline or 25 micrograms/microliter/hr or 50 micrograms/microliter/hr of morphine sulfate. During five days of infusion individual groups of rats were assessed on either the nociceptive tail flick or hot plate test. After the infusions, the analgesic effects of either subcutaneous or(More)
Animals were implanted subcutaneously with morphine or placebo pellets and assessed daily on the hot plate or the tail flick test. After tolerance developed to morphine-induced analgesia the response to an acute systemic (1-6 mg/kg SC) or intrathecal morphine injection (0-30 micrograms) was determined. "Cross-tolerance" was observed on both the hot plate (6(More)
The rapid expansion of production of North American petroleum crude oil from shale has led to a significant increase in rail transport of crude oil. Broken rails are frequent causes of train accidents. Ultrasonic rail defect inspection is widely used to prevent train accidents caused by broken rails, thereby reducing the hazardous materials transportation(More)
Examination of the binding of (+)[3H]SKF 10,047 to rat brain membranes indicated that at a low concentration most of the binding was to the haloperidol-sensitive binding site. Titration curves exhibited a displacement potency order of haloperidol greater than (+)SKF 10,047 = 1,3-diorthotolyl-guanidine much much greater than (-)SKF 10,047 much greater than(More)
The binding of [125I]beta h-endorphin to rat brain membranes was investigated in the presence of GTP and guanylyl-5'-imidodiphosphate. In contrast to the binding of the mu-selective opioid agonist, [3H][D-Ala2,MePhe4,Glyol5]enkephalin, and the delta-selective opioid agonist, [3H][D-penicillamine2, D-penicillamine5]enkephalin, [125I]beta h-endorphin binding(More)
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