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BACKGROUND AND PURPOSE Abuse of the popular recreational drug "Ecstasy" (MDMA) has been linked to the occurrence of cerebrovascular accidents. It is known that MDMA alters brain serotonin (5-HT) concentrations and that brain postsynaptic 5-HT(2) receptors play a role in the regulation of brain microvasculature. Therefore, we used brain imaging to find out(More)
BACKGROUND 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") is known to damage brain serotonin neurons in animals and possibly humans. Because serotonergic damage may adversely affect memory, we compared verbal memory function between MDMA users and MDMA-naïve control subjects and evaluated the relationship between verbal memory function and neuronal(More)
PURPOSE To evaluate the effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on the human brain by using diffusion and perfusion magnetic resonance (MR) imaging. MATERIALS AND METHODS Eight abstinent ecstasy users and six ecstasy nonusers underwent diffusion and perfusion MR imaging. Apparent diffusion coefficient and relative cerebral volume maps(More)
PURPOSE To compare two magnetic resonance (MR) imaging techniques for demonstration of vascular contact with the trigeminal nerve. MATERIALS AND METHODS Thirteen patients with unilateral trigeminal neuralgia and 50 control subjects underwent three-dimensional fast inflow with steady-state precession (FISP) and contrast material-enhanced(More)
BACKGROUND AND PURPOSE Results of endovascular treatment of PICA aneurysms are not well established. The purpose of this study was to report incidence, clinical presentation, and outcome of endovascular treatment in 46 patients with 47 posterior inferior cerebellar artery (PICA) aneurysms. MATERIALS AND METHODS Of 2169 aneurysms treated between January(More)
BACKGROUND AND PURPOSE Routine CT of the brain is traditionally performed with sequential CT. We assessed whether sequential CT can be replaced with thinly collimated multisection spiral CT without loss of image quality. MATERIALS AND METHODS An observer study was conducted using data from 23 patients who were scanned with both a sequential (collimation,(More)
BACKGROUND Angiogenesis inhibition is a rational treatment strategy for high-grade glioma (HGG). Combined antiangiogenic therapy and chemotherapy could be beneficial, taking advantage of different mechanisms of antitumour activity of both therapies. We carried out a phase I-II clinical trial with the combination of bevacizumab and continuous dose-intense(More)
PURPOSE To investigate whether coronal multiplanar reconstruction (MPR) images of the petrosal bone from axial spiral computed tomographic (CT) data obtained with 0.5-mm collimation can replace direct coronal sequential CT scans obtained with 0.5- or 1.0-mm collimation. MATERIALS AND METHODS The differences in diagnostic quality between thin-section(More)
OBJECTIVE To define neuroimaging characteristics of peroxisome biogenesis disorders (PBD) with prolonged survival belonging to the Zellweger spectrum (ZeS). METHODS The authors studied MR images of 25 patients surviving the first year. Neuroimages were compared to neurologic profiles, PBD-ZeS specific compound developmental scores, and two common PEX1(More)