C Azoulay-Barjonet

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GnRH analogs are widely used in reproductive medicine to create a hypogonadotropic hypogonadism. However, numerous animal studies have demonstrated a direct regulation of the gonadal function by GnRH. To ascertain this direct ovarian effect in humans, the steroidogenesis of cultured human granulosa cells was studied with or without GnRH and five of its(More)
Human luteal granulosa cells, harvested from preovulatory follicles during in vitro fertilization attempts, were cultured in a serum-precoated substratum ('serum cells') or on a collagen matrix ('collagen cells'). Concerning the 'serum cell' model, E2 secretion was very low in the absence of androgen; when androstenedione was added to the culture medium,(More)
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