C. Albert Thompson

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In this paper, we investigate model-driven engineering, reporting on an exploratory case-study conducted at a large automotive company. The study consisted of interviews with 20 engineers and managers working in different roles. We found that, in the context of a large organization, contextual forces dominate the cognitive issues of using model-driven(More)
Cortical spreading depression (CSD) induces waves of neuronal depolarization that confer neuroprotection to subsequent ischemic events in the rat brain. To gain insights into the molecular mechanisms elicited by CSD, we used representational difference analysis (RDA) to identify mRNAs induced by potassium depolarization in vivo. Using this approach, we have(More)
Bronchial smooth muscle cell (BSMC) hyperplasia is a typical feature of airway remodeling and contributes to airway obstruction and hyperresponsiveness in asthma. Fibroblast growth factor 2 (FGF-2) and transforming growth factor beta1 (TGF-beta1) are sequentially upregulated in asthmatic airways after allergic challenge. Whereas FGF-2 induces BSMC(More)
Cell growth and terminal differentiation are controlled by complex signaling cascades that regulate the expression of specific subsets of genes controlling cell fate and morphogenic processes. We have recently cloned and characterized a novel Ste20-like kinase termed SLK (Sabourin et al., Mol. Cel. Biol. 20 (2000) 684). However, the specific function of SLK(More)
When starting a new task, a software developer must typically find one or more starting points amongst many resources (e.g., source code and other files) forming the software system. In this paper, we consider how we might recommend one resource as an initial starting point, saving the developer the effort of having to search or use other means to find the(More)
Mice that lack tumor necrosis factor-alpha (TNF) receptors are more susceptible than wild-type animals to brain injury produced by kainic acid or transient focal ischemia suggesting that the rapid production of TNF that occurs after these insults serves a neuroprotective role. The mechanisms by which TNF reduces neuronal loss after brain injury may involve(More)
Software developers use issues as a means to describe a range of activities to be undertaken on a software system, including features to be added and defects that require fixing. When creating issues, software developers expend manual effort to specify relationships between issues, such as one issue blocking another or one issue being a sub-task of another.(More)
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