C. A. Kelleher

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The hematopoietic growth factors granulocyte/macrophage colony-stimulating factor (GM-CSF) and G-CSF, available as recombinant products, stimulate the growth in culture of blasts from patients with acute myeloblastic leukemia (AML). We used cDNA probes for each gene to study the genomic organization in blast cells of 22 patients and expression in the blast(More)
The blast stem cells of acute myeloblastic leukemia (AML) respond in cell culture to growth factors by both self-renewal and terminal divisions. Both of these functions have been shown to be stimulated by the recombinant growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). In this paper,(More)
The blast stem cells of acute myeloblastic leukemia (AML) respond in cell culture to growth factors by both selfrenewal and terminal divisions. Both of these functions have been shown to be stimulated by the recombinant growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). In this paper.(More)
We have proposed that the blasts in acute myeloblastic leukemia (AML) are renewal populations maintained by a small subpopulation of stem cells. The balance between self-renewal and differentiation in blast stem cells may be an important attribute contributing to treatment outcome. Cytosine arabinoside (ara-C) is included in most chemotherapeutic regimens(More)
The absorption of labelled molybdenum compounds was studied in pairs of sheep exchanging digesta via re-entrant duodenal cannulae. Tri- and tetrathiomolybdate 99Mo were rapidly absorbed from the rumen to circulate in plasma in a protein-bound and in a TCA-insoluble form. The compounds were also absorbed from the small intestine although some breakdown was(More)
Plasma diethylsuccinate carboxylesterase activity in plasma was elevated within 7 days in 4 sheep which received 4 mg Cu per kg body weight in gelatin capsules daily for 100 days followed by the same amount of Cu as a drench until the haemolytic crisis commenced. Plasma aspartate amino-transferase and sorbitol dehydrogenase activities in plasma were not(More)
The genes for the hemopoietic growth factors, GM colony-stimulating factor (CSF) and G-CSF have been cloned, and recombinant material is available for both. We tested these recombinant factors for their effects on the blast cells of acute myeloblastic leukemia (AML). Culture methods are available that support both colony formation by AML blasts and the(More)
1. Rams, fauna-free from birth and initially of 48-65 kg live weight, were allocated to two groups of ten each and given a diet containing 14 micrograms copper/g dry matter; five additional rams were killed and their livers were analysed for Cu. 2. One group (faunated) was inoculated with a mixed population of ciliate protozoa, and contained between 60 x(More)
1. Protein-bound, trichloracetic acid- (TCA) insoluble 99Mo appeared in plasma a few hours after the introduction of 99Mo-labelled molybdate (30 mg Mo) into the rumen of sheep maintained on a basic diet supplemented with elemental sulphur (3 g S/d). 2. Most of the 99Mo could be displaced from its protein carrier in vitro and the labelled compounds displaced(More)