C A E Rigters-Aris

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Dear Sir, `t Hart et al. [1] analysed the association of two previously reported single nucleotide polymorphisms in the sulphonylurea receptor gene (SUR1) [2] with Type II (non-insulin-dependent) diabetes mellitus in the Netherlands [1]. They reported an association of the exon 16±3t variant with Type II diabetes mellitus by showing that the genotype(More)
OBJECTIVE To determine a safe maximum number of artificial insemination (donor insemination [DI]) children per anonymous sperm donor. DESIGN Multiparameter calculation model of contribution of DI to inbreeding. SETTING Data of the collaborative DI centers and demographic population data of The Netherlands. INTERVENTIONS Calculations of the(More)
A genome-wide scan was performed, using nonparametric linkage analyses, to find susceptibility loci for type 2 diabetes mellitus in the Dutch population. We studied 178 families from The Netherlands, who constituted 312 affected sibling pairs. The first stage of the genome scan consisted of 270 DNA markers, with an average intermarker spacing of 13 cM.(More)
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