C. A. D. Leguy

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To assess in clinical practice arterial blood volume flow (BVF) from ultrasound measurements, the assumption is commonly made that the velocity profile can be approximated by a quasi-static Poiseuille model. However, pulsatile flow behaviour is more accurately described by a Womersley model. No clinical studies have addressed the consequences on the(More)
To estimate arterial stiffness, different methods based either on distensibility, pulse wave velocity or a pressure-velocity loop, have been proposed. These methods can be employed to determine the arterial mechanical properties either locally or globally, e.g. averaged over an entire arterial segment. The aim of this study was to investigate the(More)
Non-invasive estimation of arterial blood volume flow (BVF) has become a central issue in assessment of cardiovascular risk. Poiseuille and Womersley approaches are commonly used to assess the BVF from centerline velocity, but both methods neglect the influence of curvature. Based on the assumption that the velocity in curved tubes as function of the(More)
Wave propagation models of blood flow and blood pressure in arteries play an important role in cardiovascular research. For application of these models in patient-specific simulations a number of model parameters, that are inherently subject to uncertainties, are required. The goal of this study is to identify with a global sensitivity analysis the model(More)
The calf muscle pump is a mechanism which increases venous return and thereby compensates for the fluid shift towards the lower body during standing. During a muscle contraction, the embedded deep veins collapse and venous return increases. In the subsequent relaxation phase, muscle perfusion increases due to increased perfusion pressure, as the proximal(More)
Task farming is often used to enable parameter sweep for exploration of large sets of initial conditions for large scale complex simulations. Available solutions enable to perform parameter sweep by creating multiple grid job submissions with different parameters. This paper presents an approach to farm grid workflows with a web service based workflow(More)
Chronic venous disease is defined as dysfunction of the venous system caused by incompetent venous valves with or without a proximal venous obstruction. Assessing the severity of the disease is challenging, since venous function is determined by various interacting hemodynamic factors. Mathematical models can relate these factors using physical laws and can(More)
Ballistocardiography is a non-invasive technique to estimate heart function and relative changes in cardiac output. The goal of this study was to establish the relationship between ballistocardiogram (BCG) parameters and changes in cardiovascular parameters. A group of 20 subjects performed three different exercises on a force plate. In this study, we have(More)
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