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- Tabassome Simon, Céline Verstuyft, +7 authors Laurent Becquemont
- The New England journal of medicine
- 2009
BACKGROUND
Pharmacogenetic determinants of the response of patients to clopidogrel contribute to variability in the biologic antiplatelet activity of the drug. The effect of these determinants on… (More)
- Laurent Bodin, Céline Verstuyft, +8 authors Marie-Anne Loriot
- Blood
- 2005
The aim of the study is to explore the contribution of genetic factors related either to drug metabolism (cytochrome P450 2C9) or to drug target (vitamin K epoxide reductase) to variability in the… (More)
- Henriette Elisabeth Meyer zu Schwabedissen, Céline Verstuyft, Heyo Klaus Kroemer, Laurent Becquemont, Richard B Kim
- American journal of physiology. Renal physiology
- 2010
Renal elimination of a number of cationic compounds is thought to be mediated by the organic cation transporter 2 (OCT2, SLC22A2), a drug uptake transporter expressed at the basolateral domain of… (More)
- Céline Verstuyft, Mathias Schwab, +5 authors Laurent Becquemont
- European Journal of Clinical Pharmacology
- 2003
Background. The effect of MDR1 C3435T single nucleotide polymorphism (SNP) in exon 26 on digoxin pharmacokinetics has recently been challenged. Objective. To clarify the relationships between MDR1… (More)
- Laurent Coulbault, Marc Beaussier, +8 authors Laurent Becquemont
- Clinical pharmacology and therapeutics
- 2006
OBJECTIVE
The aim of this study was to investigate the respective influence of genetic and nongenetic factors on morphine dose requirements and adverse effects after colorectal surgery.
METHODS… (More)
- Monidarin Chou, Julie Bertrand, +8 authors A -M. Taburet
- Antimicrobial agents and chemotherapy
- 2010
The aims of this ANRS12154 open-label, single-center, multiple-dose pharmacokinetic study were to characterize nevirapine pharmacokinetics in a Cambodian population of HIV-infected patients and to… (More)
- Jue Quin Yang, Sandrine Morin, +7 authors Laurent Becquemont
- Fundamental & clinical pharmacology
- 2003
Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme responsible for the metabolism of different drugs with low therapeutic index such as oral anticoagulants. CYP2C9*2 and CYP2C9*3 are two single… (More)
- Dany Anglicheau, Céline Verstuyft, +6 authors Eric Thervet
- Journal of the American Society of Nephrology…
- 2003
The immunosuppressive drug tacrolimus, whose pharmacokinetic characteristics display large interindividual variations, is a substrate for P-glycoprotein (P-gp), the product of the multidrug… (More)
- Corinne Miceli-Richard, Emmanuelle Comets, +7 authors Xavier Mariette
- Annals of the rheumatic diseases
- 2008
OBJECTIVE
To determine whether tumour necrosis factor (TNF) gene polymorphisms and/or the shared epitope are genetic predictors of the response to adalimumab (ADA) in rheumatoid arthritis (RA).
… (More)
- Laurent Becquemont, Céline Verstuyft, +4 authors Christian Funck-Brentano
- Clinical pharmacology and therapeutics
- 2001
OBJECTIVES
Grapefruit juice is responsible for drug interactions mediated by intestinal cytochrome P4503A4 inhibition and possibly P-glycoprotein inhibition in enterocytes. Our main objective was to… (More)