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Actuaries usually compute multiple life premiums based on the unrealistic assumption of independence of the lifelengths of insured persons. Many clinical studies, however, have demonstrated… (More)
This thesis develops an integrated methodology based on the desirability index and QSAR models to virtually optimise molecules. Statistical and algorithmic tools are proposed to search in huge… (More)
Optimizing the quality of a product is widespread in the industry. Products have to be manufactured such that they best fit some quality properties. Varying the product settings leads to different… (More)
Background Odanacatib (ODN) is an orally-active cathepsin K inhibitor being developed for the treatment of postmenopausal osteoporosis. Objectives This study evaluated the effects of ODN 50mg once… (More)