Céline Huynen

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Thirty-six patients with pathology in the area of the craniocervical junction and the cervical spine have been studied with Magnetic Resonance Imaging (MRI), using the Inversion Recovery and Spin-Echo technique. The value of MRI for diagnosis and management is compared, in retrospect, to X-ray Computer Tomography and Myelography. The conclusion is that MRI(More)
Polyglutamine (polyQ) diseases, including Huntington's disease, are neurodegenerative disorders associated with the abnormal expansion of a polyQ tract within nine proteins. The polyQ expansion is thought to be a major determinant in the development of neurotoxicity, triggering protein aggregation into amyloid fibrils, although non-polyQ regions play a(More)
Designing hybrid proteins is a major aspect of protein engineering and covers a very wide range of applications from basic research to medical applications. This review focuses on the use of class A β-lactamases as versatile scaffolds to design hybrid enzymes (referred to as β-lactamase hybrid proteins, BHPs) in which an exogenous peptide, protein or(More)
A 16-year-old girl developed left hemispheric deficits, which were followed by clouding of consciousness, quadriplegia, and subcortical blindness. Although we could not demonstrate a recent viral infection, the clinical features, laboratory and radiologic findings strongly suggested the diagnosis acute disseminated encephalitis. Cerebrospinal fluid(More)
The preliminary results are presented of a comparative study between MRI and CT in 150 patients from the University Hospital Utrecht. The purpose is through a prospective study to make more definitive assessments about the role and the value of MRI in the region of the brain and cervical spine. If compared with CT, no abnormalities were missed with MRI in(More)
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