Céline Bonhomme

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DNA double-strand break (DSB) repair interferes with ongoing cellular processes, including replication and transcription. Although the process of replication stalling upon collision of replication forks with damaged DNA has been extensively studied, the fate of elongating RNA polymerase II (RNAPII) that encounters a DSB is not well understood. We show that(More)
Piribedil ([1-(3,4-methylenedioxybenzyl)-4-(2-pyrimidinyl)piperazine]; S 4200) is a dopamine agonist with equal affinity for D(2)/D(3) dopamine receptors effective in treating Parkinson's disease as monotherapy or as an adjunct to levodopa (L-dopa). However, its ability to prime basal ganglia for the appearance of dyskinesia is unknown. We now report on the(More)
Over the past decade, neutral theory has gained attention and recognition for its capacity to explain bacterial community structure (BCS) in addition to deterministic processes. However, no clear consensus has been drawn so far on their relative importance. In a metacommunity analysis, we explored at the regional and local scale the effects of these(More)
The suitability of a commonly used accumulation and wash-off model for continuous modelling of urban runoff contamination was evaluated based on 11-month turbidity and flow-rate records from an urban street. Calibration and uncertainty analysis were performed using a Markov Chain Monte-Carlo sampling method for both suspended solids loads (discharge rates)(More)
This study evaluates the influence of a heavily urbanized area (Paris Metropolitan area), on receiving water contamination by both bisphenol A (BPA) and alkylphenol ethoxylate (APE) biodegradation product. The study began by investigating concentrations within urban sources. In addition to the more commonly studied wastewater treatment plant effluent, wet(More)
Considering fault current limiters for serial protection, a number of structures exist, from regulation to other complex systems such as circuit breakers, mechanical switches or more conventional fuses. Up to now, only few semiconductor current limiter structures have been described in the literature. Although current regulative diode components already(More)
Methods for simulating air pollution due to road traffic and the associated effects on stormwater runoff quality in an urban environment are examined with particular emphasis on the integration of the various simulation models into a consistent modelling chain. To that end, the models for traffic, pollutant emissions, atmospheric dispersion and deposition,(More)
Assessing the fate of endocrine disrupting compounds (EDCs) in the environment is currently a key issue for determining their impacts on aquatic ecosystems. The 4-nonylphenol (4-NP) is a well known EDC and results from the biodegradation of surfactant nonylphenol ethoxylates (NPnEOs). Fate mechanisms of NPnEO are well documented but their rate constants(More)
Stormwater quality modeling has arisen as a promising tool to develop mitigation strategies. The aim of this paper is to assess the build-up and wash-off processes and investigate the capacity of several water quality models to accurately simulate and predict the temporal variability of suspended solids concentrations in runoff, based on a long-term data(More)
Nowadays, the increasing use of vehicles is causing contaminated stormwater runoff to drain from roads. The detailed understanding of urban wash-off processes is essential for addressing urban management issues. However, existing modelling approaches are rarely applied for these objectives due to the lack of realistic input data, unsuitability of physical(More)