Céline Bonhomme

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Piribedil ([1-(3,4-methylenedioxybenzyl)-4-(2-pyrimidinyl)piperazine]; S 4200) is a dopamine agonist with equal affinity for D(2)/D(3) dopamine receptors effective in treating Parkinson's disease as monotherapy or as an adjunct to levodopa (L-dopa). However, its ability to prime basal ganglia for the appearance of dyskinesia is unknown. We now report on the(More)
Assessing the fate of endocrine disrupting compounds (EDCs) in the environment is currently a key issue for determining their impacts on aquatic ecosystems. The 4-nonylphenol (4-NP) is a well known EDC and results from the biodegradation of surfactant nonylphenol ethoxylates (NPnEOs). Fate mechanisms of NPnEO are well documented but their rate constants(More)
Introduction: The primitive carbonaceous chondrites contain substantial amounts of carbon (up to 3%), mostly as macromolecular insoluble organic matter (IOM). This IOM is considered as a record of interstellar synthesis and may contain precursors of prebiotic molecules possibly deposited on earth by meteoritic bombardments. For these reasons, chondritic IOM(More)
Stormwater quality modeling has arisen as a promising tool to develop mitigation strategies. The aim of this paper is to assess the build-up and wash-off processes and investigate the capacity of several water quality models to accurately simulate and predict the temporal variability of suspended solids concentrations in runoff, based on a long-term data(More)
This study aims at modelling the daily concentrations of nonylphenolic compounds such as 4-nonylphenol (4-NP), nonylphenol monoethoxylate (NP1EO) and nonylphenoxy acetic acid (NP1EC) within the Seine River downstream of Paris City for over a year, firstly in the present state (year 2010) and for years 2050 and 2100 in order to assess the consequences of(More)
INTRODUCTION Hemiplegic (or spastic unilateral) cerebral palsy accounts for about 30% of all cases of cerebral palsy. With a population prevalence of 0.6 per 1000 live births, it is the most common type of cerebral palsy among term-born children and the second most common type after diplegia among preterm infants. STATE OF THE ART Many types of prenatal(More)
The ability of transdermal administration of the dopamine D2/D3 agonist piribedil (1-[3,4-methylenedioxybenzyl)]-4-[(2-pyrimidinyl)]piperazine) to reverse hypokinesia and other motor deficits observed in MPTP-treated common marmosets was investigated. Piribedil (2.5-10.0 mg/animal), applied directly to the skin of the abdomen as a paste, produced a(More)
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