Célia Francisca dos Santos

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The unarguably fast, and continuous, growth of the volume of indexed (and indexable) documents on the Web poses a great challenge for search engines. This is true regarding not only search effectiveness but also time and space efficiency. In this paper we present an index pruning technique targeted for search engines that addresses the latter issue without(More)
Recently, we have found that the skin secretions of the Amazonian tree frog Phyllomedusa bicolor contains molecules with antitumor and angiostatic activities and identified one of them as the antimicrobial peptide dermaseptin (Drs) B2. In the present study we further explored the in vitro and in vivo antitumor activity of this molecule and investigated its(More)
This article discusses a novel approach developed for static index pruning that takes into account the locality of occurrences of words in the text. We use this new approach to propose and experiment on simple and effective pruning methods that allow a fast construction of the pruned index. The methods proposed here are especially useful for pruning in(More)
Galunisertib (LY2157299) is a selective ATP-mimetic inhibitor of TGF-β receptor (TβR)-I activation currently under clinical investigation in hepatocellular carcinoma (HCC) patients. Our study explored the effects of galunisertib in vitro in HCC cell lines and ex vivo on patient samples. Galunisertib was evaluated in HepG2, Hep3B, Huh7, JHH6 and SK-HEP1(More)
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