Cédric F. Invernizzi

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BACKGROUND The HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNA through interaction with the Rev response element (RRE) by means of an arginine rich motif that is similar to the one found in Tat. Since Tat is known to be asymmetrically arginine dimethylated by protein arginine methyltransferase 6 (PRMT6) in its arginine(More)
Numerous studies have suggested that the K65R reverse transcriptase (RT) mutation develops more readily in subtype C than subtype B HIV-1. We recently showed that this discrepancy lies partly in the subtype C template coding sequence that predisposes RT to pause at the site of K65R mutagenesis. However, the mechanism underlying this observation and the(More)
OBJECTIVE a) To assess the suitability of the curriculum content and didactical quality of information delivered to educate journalists in the J2J program in HIV/AIDS (process evaluation) and b) to explore the effects of such programs on journalists' reporting of HIV/AIDS related information (outcome evaluation). DESIGN Descriptive study. METHODS For(More)
OBJECTIVES We recently reported the preferential selection of the K65R resistance mutation in subtype C HIV-1 compared with subtype B and showed the underlying mechanism to be dependent on subtype C-specific silent nucleotide polymorphisms, i.e. genomic mutations that change the genotype but not the phenotype. The number of clinical reports demonstrating(More)
Objectives Patients carrying subtype C viruses in Botswana, Malawi, and South Africa are prone to develop the K65R mutation in RT after receiving d4T or ddI/d4T in therapy. We have studied the effect of subtype C polymorphisms at position 64/65 and at TAM sites (70, 210, 219) in RT on pathway outcome in cell culture, utilizing N(t)RTI drug pressure alone(More)
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