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OBJECTIVES This preliminary study aimed to determine whether augmented renal clearance (ARC) impacts negatively on the clinical outcome in traumatic brain-injured patients (TBI) treated for a first(More)
This study assessed whether augmented renal clearance (ARC) impacts negatively on antibiotic concentrations and clinical outcomes in patients treated by high-dose β-lactams administered continuously.(More)
Purpose: To determine whether augmented renal clearance (ARC) impacts negatively on piperacillin‐tazobactam unbound concentrations in critically ill patients receiving 16 g/2 g/day administered(More)
In the critical care setting, augmented renal clearance (ARC) is increasingly recognized as one of the leading causes of subtherapeutic antibiotic exposure [1]. However, commonly used formulas for(More)