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Sequentially acting Sox transcription factors in neural lineage development.
Pluripotent embryonic stem (ES) cells can generate all cell types, but how cell lineages are initially specified and maintained during development remains largely unknown. Different classes of SoxExpand
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SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs
Stem cells are defined by their capacities to self-renew and generate progeny of multiple lineages. The transcription factor SOX2 has key roles in the regulation of stem cell characteristics, butExpand
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Distinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells.
Spatially distinct gene expression profiles in neural stem cells (NSCs) are a prerequisite to the formation of neuronal diversity, but how these arise from the regulatory interactions betweenExpand
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Sequentially acting SOX proteins orchestrate astrocyte‐ and oligodendrocyte‐specific gene expression
SOX transcription factors have important roles during astrocyte and oligodendrocyte development, but how glial genes are specified and activated in a sub‐lineage‐specific fashion remains unknown.Expand
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SOX transcription factors : multifaceted regulators of central nervous system development
The central nervous system (CNS) is composed of three major cell types, namely neurons, astrocytes and oligodendrocytes that are mainly generated during embryonic stages by multipotent neuralExpand
Restriction of chromatin accessibility is necessary for appropriate enhancer expression
Tissue specific gene expression underpins cell type diversity, and arises from the cooperative activities of transcription factors and the chromatin landscape. It has been previously demonstratedExpand