BACKGROUND Psychogenic non-epileptic seizures (PNES) or attacks consist of paroxysmal behavioural changes that resemble an epileptic seizure but are not associated with electrophysiological epileptic changes. They are caused by a psychopathological process and are primarily diagnosed on history and video-EEG. Clinical presentation comprises a wide range of… (More)
BACKGROUND Recent neuroimaging studies point to a possible pathophysiological role of cerebellar dysfunction in dystonia. The authors investigated the association between sensorimotor adaptation, cerebellar dysfunction and the myoclonus-dystonia phenotype. METHODS The authors prospectively analysed reactive saccade adaptation in a genetically homogeneous… (More)
Mirror movements are involuntary symmetrical movements of one side of the body that mirror voluntary movements of the other side. Congenital mirror movement disorder is a rare condition characterized by mirror movements that persist throughout adulthood in subjects with no other clinical abnormalities. The affected individuals have mirror movements… (More)
Sir, In their Letter to the Editor, Linssen et al. (2014) report the failure of a single session of continuous theta burst tran-scranial magnetic stimulation (TBS) of posterior cerebellum to improve the writing performance of patients with wri-ter's cramp. The authors state that they derived the rationale for their study from the conclusions of our study… (More)
OBJECTIVE To evaluate the efficacy and safety of zonisamide in patients with myoclonus-dystonia. METHODS We conducted a randomized, double-blind, placebo-controlled crossover trial of zonisamide (300 mg/d) in 24 patients with myoclonus-dystonia. Each treatment period consisted of a 6-week titration phase followed by a 3-week fixed-dose phase. The periods… (More)
TRIAL REGISTRATION ClinicalTrials.gov NCT01341431.
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IMPORTANCE Myoclonus-dystonia (M-D) is a clinical syndrome characterized by a combination of myoclonic jerks and mild to moderate dystonia. The syndrome is related to ε-sarcoglycan (SGCE) gene mutations in about half the typical cases. Whether the M-D phenotype reflects a primary dysfunction of the cerebellothalamocortical pathway or of the… (More)