Cécile Guillot-Gueguen

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Despite the effectiveness of immunosuppressive drugs, kidney transplant recipients still face late graft dysfunction. Thus, it is necessary to identify biomarkers to detect the first pathologic events and guide therapeutic target development. Previously, we identified differences in the T-cell receptor Vβ repertoire in patients with stable graft function.(More)
In order to characterize the reactivity of B cells against nominal antigens, a method based on the coupling of antigens onto the surface of fluorescent core polystyrene beads was developed. We first demonstrate that murine B cells with a human MOG-specific BCR are able to interact with MOG-coated beads and do not recognize beads coated with human albumin or(More)
Results We show that T cell monitoring, and especially CD8 TCR repertoire alterations, may allow identifying patients at risk of graft dysfunction. As compared to patients without TCR Vb repertoire alterations, patients with an altered TCR Vb repertoire at the inclusion have a 2.1 fold higher risk of graft dysfunction during their follow-up. The Vb(More)
Despite their utility, immunosuppressive treatments have numerous side effects, including infectious complications, malignancies and metabolic disorders, all of which contribute to long-term graft loss. In addition to the development of new pharmaceutical products with reduced toxicity and more comfortable modes of administration, tailoring(More)
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