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Antibacterial activity of some African medicinal plants used traditionally against infectious diseases
This study supports the use of most of the studied plants in traditional medicine, for the treatment of infectious diseases, and some of them are worthy of further investigation. Expand
Developing countries, where malaria is endemic, depend strongly on traditional medicine as a source for inexpensive treatment of this disease. However, scientific data to validate the antimalarialExpand
Inhibition of efflux pumps in methicillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina.
Six cucurbitane-type triterpenoids (1-6) isolated from the aerial parts of Momordica balsamina were evaluated for their ability to inhibit the activity of bacterial efflux pumps ofExpand
Isoflavones as Apoptosis Inducers in Human Hepatoma HuH‐7 Cells
Nine flavonoid isolated from the ethyl acetate extract of Pycnanthus angolensis were assayed for their potential apoptosis induction activities in human hepatoma HuH‐7 cells and caspase activity assays confirmed the apoptosis inducing activity of these flavonoids. Expand
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
In the checkerboard model of combination chemotherapy, the interaction between doxorubicin and compounds 2-5 synergistically enhanced the effect of the anticancer drug. Expand
Cucurbitane-type triterpenoids from the African plant Momordica balsamina.
Phytochemical investigation of the aerial parts of Momordica balsamina led to the isolation of five new cucurbitane-type triterpenoids (1-5) and two known analogues (6, 7). Their structures wereExpand
Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species.
Seven known pentacyclic triterpenes and one steroid were isolated from Euphorbia lagascae methanolic extracts and identified by physical and spectroscopic methods, and apoptosis induction activities were tested by flow cytometry on L5178 human MDR1 gene-transfected mouse lymphoma cells. Expand
New antimalarials with a triterpenic scaffold from Momordica balsamina.
Bioassay-guided fractionation of the methanol extract of Momordica balsamina led to the isolation of three new cucurbitane-type triterpenoids, balsaminols C-E, which displayed antimalarial activity and the preliminary toxicity toward human cells of compounds 1-5 and 9 was investigated in breast cancer cell line. Expand
Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections.
Active compounds were shown to inhibit the parasite's intracellular development rather than its ability to invade hepatic cells, and toxicity of compounds 1-6 towards human cells was also investigated, showing that they were not toxic or exhibited weak toxicity. Expand
Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans.
Three novel beta-carboline indole alkaloids (1-3) have been isolated from a MeOH extract of the leaves of Tabernaemontana elegans by means of spectroscopic techniques including 2D NMR experiments. Expand