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Differential Epigenetic Effects of Atmospheric Cold Plasma on MCF-7 and MDA-MB-231 Breast Cancer Cells
TLDR
Results indicate that plasma induces epigenetic and cellular changes in a cell type-specific manner, suggesting that a careful screening of target cells and tissues is necessary for the potential application of plasma as a cancer treatment option. Expand
Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer
TLDR
Different epigenetic status including promoter methylation and different responses through the ER are involved in the differential expression of MTO1 and MRPL41 in breast cancer. Expand
Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin
TLDR
Structural differences between the LF isoforms, mainly glycosylation, determine the fate of LF signaling, and these findings provide information relating to the role of ΔLF which is downregulated during carcinogenesis. Expand
SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells.
TLDR
Findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation. Expand
Stage-specific methylome screen identifies that NEFL is downregulated by promoter hypermethylation in breast cancer.
TLDR
These findings may lend credence to the possibility of using tumor stage-specific alterations in methylation patterns as biomarkers for estimating prognosis and assessing treatment options for breast cancer. Expand
Epigenetically regulated Fibronectin leucine rich transmembrane protein 2 (FLRT2) shows tumor suppressor activity in breast cancer cells
TLDR
The results provide insights into the role of FLRT2 as a novel tumor suppressor in the breast, which is inactivated by hypermethylation during tumor development. Expand
Proton Beams Inhibit Proliferation of Breast Cancer Cells by Altering DNA Methylation Status
TLDR
It is demonstrated that proton beam-induced physiological changes of cancer cells via methylation modification assists in establishing the epigenetic basis of protonbeam therapy for cancer. Expand
Identification and Comparison of Aberrant Key Regulatory Networks in Breast, Colon, Liver, Lung, and Stomach Cancers through Methylome Database Analysis
TLDR
The genome-wide methylation analysis on each 10 sets of normal and cancer pairs of five tissues revealed that breast cancer was closest with lung cancer, whereas it was farthest from colon cancer, and the novel methylation markers could be applied to establish markers for cancer prognosis. Expand
Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene
Mbu-1 (Csrnp-3) is a mouse gene that was identified in our previous study as showing highly restricted expression to the central nervous system. In this study, to elucidate the regulatory mechanismExpand
Human lactoferrin upregulates BCL-3 in the K562 erythroleukemia cell
TLDR
It is suggested that LF signals to induce BCL-3 and thereby promotes B cell proliferation and survival. Expand