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Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy(More)
OBJECT Ideal epilepsy surgery would eliminate seizures without causing any functional deficits. The aim of the present study was to assess seizure outcomes and complications after epilepsy surgery in children with intractable epilepsy. METHODS Data obtained in 134 children (75 boys and 59 girls) age 17 years or younger who underwent epilepsy surgery at(More)
Mesenchymal stem cells (MSCs) have an extensive migratory capacity for gliomas, which is comparable to that of neural stem cells. Among the various types of MSCs, human adipose tissue-derived MSCs (hAT-MSC) emerge as one of the most attractive vehicles for gene therapy because of their high throughput, lack of ethical concerns, and availability and ease of(More)
OBJECTIVE To investigate the age, gender, location and pathologic diagnosis of brain tumors in pediatric patients (less than 16 years old), we reviewed 677 patients who were operated on at the Department of Neurosurgery, Seoul National University Hospital (SNUH) during the period from January 1959 to June 2000. PATIENTS AND METHODS Only tumors for which(More)
Ganglioglioma is increasingly recognized as being a cause of epilepsy. However, controversy still exists regarding the type of surgery required for optimal seizure control. To find out the factors associated with seizure outcome and to clarify treatment guidelines, a retrospective analysis of 29 epileptic patients who had pathologically proven(More)
OBJECTIVE The prognosis for moyamoya disease (MMD) among young patients is known to be worse than that among older patients. The aim of this study was to investigate the clinical features and treatment outcomes of young patients with MMD. METHODS A total of 204 patients with MMD who underwent encephaloduroarteriosynangiosis, with or without bifrontal(More)
OBJECTIVE We compared the surgical results of simple encephaloduroarteriosynangiosis (EDAS) and EDAS with bifrontal encephalogaleo(periosteal)synangiosis for the treatment of pediatric moyamoya disease. METHODS Data for 159 children (up to 15 yr of age, 76 boys and 83 girls) who underwent indirect revascularization procedures for the treatment of moyamoya(More)
BACKGROUND Most craniopharyngiomas can be classified as either "prechiasmatic" or "retrochiasmatic" according to their growth patterns. The purpose of our study was to investigate the factors determining these growth patterns. METHODS The radiological, operative, and pathological findings of 25 consecutive cases were reviewed. RESULTS In cases with(More)
OBJECT Patients with moyamoya disease complain of headache before surgery, after surgery, or in both periods. To clarify the pathophysiological features of these headaches which are one of the major symptoms in moyamoya disease after indirect bypass surgery, the authors reviewed data obtained in patients with moyamoya disease who underwent such surgery at(More)
In order to investigate the clinical characteristics, neuroimaging findings, pathological features, treatment, and outcomes, and to provide valuable guidance for the diagnosis and management of intracranial gangliogliomas, 34 cases of intracranial gangliogliomas were retrospectively analyzed. This study included 23 males and 11 females. Age at operation(More)