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NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.
Immunocytochemical analysis of cells transfected with NGEP cDNAs containing a Myc epitope tag at the carboxyl terminus shows that the protein encoded by the short transcript is localized in the cytoplasm, whereas the protein encode by the long transcript is present on the plasma membrane. Expand
PATE Gene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity*
These findings indicate that in addition to participation of the PATE (Pate)-like genes in functions related to fertility and reproduction, some of them likely act as important modulators of neural transmission. Expand
Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
The strong binding kinetics of the mesothelin-MUC16 interaction and the cell adhesion between ovarian tumor cells and A431-Meso+ even in the presence of peritoneal fluid strongly support the importance of these two glycoproteins in the peritoneale metastasis of ovarian tumors. Expand
A Binding Domain on Mesothelin for CA125/MUC16*
The identified CA125-binding domain significantly inhibits cancer cell adhesion and merits evaluation as a new therapeutic agent for preventing or treating peritoneal malignant tumors. Expand
POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer
expression of POTE in prostate cancer and its undetectable expression in normal essential tissues make POTE a candidate for the immunotherapy of prostate cancer. Expand
MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer
It is shown that MRP9 (ABCC12), a member of the ATP-binding cassette (ABC) superfamily, has two major transcripts of 4.5 and 1.3 kb, and it is speculated that they may have a different function from other family members. Expand
Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
To suppress the immune response, a redesigned immunotoxin with T-cell epitope mutations is highly cytotoxic to cell lines and to cells isolated from cancer patients and produces complete remissions in mice with human cancer xenografts. Expand
Characterization of the B Cell Epitopes Associated with a Truncated Form of Pseudomonas Exotoxin (PE38) Used to Make Immunotoxins for the Treatment of Cancer Patients1
The results indicate that a relatively small number of discrete immunogenic sites are associated with PE38, most of which can be eliminated by point mutations. Expand
Assessment of template‐free modeling in CASP10 and ROLL
We present the assessment of predictions for Template‐Free Modeling in CASP10 and a report on the first ROLL experiment wherein predictions are collected year round for review at the regular CASPExpand
Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes
The location and amino acid composition of all of the B-cell epitopes in the remaining 25-kDa portion of Pseudomonas exotoxin are shown, to produce an immunotoxin (HA22-LR-8M) that is fully cytotoxic against malignant B- cell lines, has high cytot toxic activity against cells directly isolated from patients with chronic lymphocytic leukemia, and has excellent antitumor activity in mice. Expand