• Publications
  • Influence
OASL1 inhibits translation of the type I interferon–regulating transcription factor IRF7
The production of type I interferon is essential for viral clearance but is kept under tight control to avoid unnecessary tissue damage from hyperinflammatory responses. Here we found that OASL1Expand
  • 92
  • 7
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.
The primary interactions between incoming viral RNA genomes and host proteins are crucial to infection and immunity. Until now, the ability to study these events was lacking. We developed viralExpand
  • 5
  • 3
Identification and Functional Analysis of Antifungal Immune Response Genes in Drosophila
Essential aspects of the innate immune response to microbial infection appear to be conserved between insects and mammals. Although signaling pathways that activate NF-κB during innate immuneExpand
  • 42
  • 2
  • PDF
Restriction of Nonpermissive RUNX3 Protein Expression in T Lymphocytes by the Kozak Sequence
The transcription factor Runx3 promotes differentiation of naive CD4+ T cells into type-1 effector T (TH1) cells at the expense of TH2. TH1 cells as well as CD8+ T cells express a subset-specificExpand
  • 7
  • 1
Requirement of Split ends for Epigenetic Regulation of Notch Signal-Dependent Genes during Infection-Induced Hemocyte Differentiation
ABSTRACT Drosophila producing a mutant form of the putative transcription coregulator, Split ends (Spen), originally identified in the analysis of neuronal development, display diverse immuneExpand
  • 13
Cutting Edge: The Histone Methyltransferase G9a Is Required for Silencing of Helper T Lineage–Associated Genes in Proliferating CD8 T Cells
Helper versus cytotoxic T lineage decision in the thymus has been studied as a model for silencing of alternative lineage genes. Although the transcription factor RUNX3 is required for the initiationExpand
  • 5
Corrigendum: OASL1 inhibits translation of the type I interferon–regulating transcription factor IRF7
Corrigendum: OASL1 inhibits translation of the type I interferon–regulating transcription factor IRF7
  • 2
Genome-wide profiling of in vivo LPS-responsive genes in splenic myeloid cells
Lipopolysaccharide (LPS), the major causative agent of bacterial sepsis, has been used by many laboratories in genome-wide expression profiling of the LPS response. However, these studies haveExpand
  • 3
Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells
The cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self. CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor proteinExpand