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Making insulin-deficient type 1 diabetic rodents thrive without insulin
- Xinxin Yu, Byung-Hyun Park, May-yun Wang, Zhao V. Wang, R. Unger
- Biology, MedicineProceedings of the National Academy of Sciences
- 16 September 2008
It is suggested that leptin reverses the catabolic consequences of total lack of insulin, potentially by suppressing glucagon action on liver and enhancing the insulinomimetic actions of IGF-1 on skeletal muscle, and suggest strategies for making type 1 diabetes insulin-independent.
Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
This study will provide valuable information not only into the mechanisms underlying β-cell destruction but also into the regulation of SIRT1 as a possible target to attenuate cytokine-inducedβ-cell damage.
Rapid transformation of white adipocytes into fat-oxidizing machines
Phosphorylation of both acetyl CoA carboxylase and AMP-activated protein kinase was increased, thus explaining the increase in fatty acid oxidation and the ability to transform adipocytes into unique fat-burning cells may suggest novel therapeutic strategies for obesity.
Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells.
Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity
The data suggest that ROS generated, in part, through the activation of NADPH oxidase plays an essential role in cisplatin ototoxicity.
Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma
This study shows that expression of DBC1 and SIRT1 is a significant prognostic indicator for gastric carcinoma patients and were independent prognostic factors significantly associated with overall survival and relapse-free survival.
Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme.
Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma.
Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis.
- Hwa-Suk Lee, S. Ka, Sang‐Myeong Lee, Sang-il Lee, Jin-woo Park, Byung-Hyun Park
- Medicine, BiologyArthritis and rheumatism
- 1 July 2013
Results suggest that blocking the NF-κB pathway by SIRT-6 in rheumatoid joints reduces both the inflammatory response and tissue destruction.