Byoung Soo Shin

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OBJECTIVE MicroRNAs play a role in atherosclerosis-related diseases, such as cerebrovascular or cardiovascular disease. However, the effect of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported. METHODS AND RESULTS Using polymerase chain reaction-amplified DNA, microRNA(More)
Paraoxonase-1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. The aims of this study were to evaluate the role of PON1 gene polymorphisms (−107C > T, L55M, and Q192R) in patients susceptible to ischemic stroke and to determine the interactive relationship between(More)
Silent brain infarction (SBI) is an asymptomatic cerebrovascular disorder. The aim of the present study was to investigate the association between adrenoceptor-α2 (ADRA2) gene polymorphisms and SBI. A total of 361 patients with SBI and 467 healthy control subjects were examined. The polymerase chain reaction was performed to genotype the ADRA2A 1780G>A,(More)
Stroke is the third most common cause of death in many developed countries, and ≈80% of strokes are ischemic in origin. In South Korea, stroke is the most frequent cause of death after cancer and is more frequent than heart disease. Multiple factors, including hypertension, diabetes mellitus, smoking, hyperlipidemia, and hyperhomocysteinemia, are associated(More)
S troke is the third most common cause of death in many developed countries, and ≈80% of strokes are ischemic in origin. In South Korea, stroke is the most frequent cause of death after cancer and is more frequent than heart disease. 3 Multiple factors, including hypertension, diabetes mellitus, smoking, hyperlipidemia, and hyperhomocysteinemia, are(More)
Stroke is the third most common cause of death in many developed countries, and ≈80% of strokes are ischemic in origin. In South Korea, stroke is the most frequent cause of death after cancer and is more frequent than heart disease. Multiple factors, including hypertension, diabetes mellitus, smoking, hyperlipidemia, and hyperhomocysteinemia, are associated(More)
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