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Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
Members of the TMEM16/ANO family of membrane proteins are Ca2+-activated phospholipid scramblases and/or Cl− channels. A membrane-exposed hydrophilic groove in these proteins serves as a sharedExpand
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Known structures and unknown mechanisms of TMEM16 scramblases and channels
The TMEM16 family of membrane proteins is composed of both Ca2+-gated Cl− channels and Ca2+-dependent phospholipid scramblases. The functional diversity of TMEM16s underlies their involvement inExpand
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Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down theirExpand
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The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.
The TMEM16 family comprises Ca2+-activated Cl- channels and phospholipid scramblases. The crystal structure of a fungal homolog, nhTMEM16, revealed an important architectural feature of this proteinExpand
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Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl−/H+ antiporter
Significance Structural studies have shown that the critical glutamate residue, Gluex, in the CLC antiporter can take 3 conformations, each of which occupies a different position along the anionExpand
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Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.
: The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down theirExpand
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Movements of individual BKCa channels in live cell membrane monitored by site-specific labeling using quantum dots.
The movements of BK(Ca) channels were investigated in live cells using quantum dots (QDs). The extracellular N-terminus was metabolically tagged with biotin, labeled with streptavidin-conjugated QDsExpand
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Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases
Significance The plasma membrane of all eukaryotic cells is asymmetric, with the signaling lipid phosphatidylserine in the cytoplasmic leaflet. When activated, membrane proteins termed phospholipidExpand
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Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+ antiporter.
The CLC family of proteins are involved in a variety of physiological processes to control cellular chloride concentration. Two distinct classes of CLC proteins, Cl− channels and Cl−/H+ antiporters,Expand
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Modulation of the conductance-voltage relationship of the BK(Ca) channel by shortening the cytosolic loop connecting two RCK domains.
Calcium-dependent gating of large-conductance calcium-activated potassium (BK(Ca)) channels is mediated by the intracellular carboxyl terminus, which contains two domains of regulator of K(+)Expand
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