Byeong-il Lee

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Optimization of the specific affinity of cardiac delivery vector could significantly improve the efficiency of gene/protein delivery, yet no cardiac vectors to date have sufficient target specificity for myocardial infarction (MI). In this study, we explored bacterial tropism for infarcted myocardium based on our previous observations that certain bacteria(More)
Multi-resolution images of histological sections of breast cancer tissue were analyzed using texture features of Haar- and Daubechies transform wavelets. Tissue samples analyzed were from ductal regions of the breast and included benign ductal hyperplasia, ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (CA). To assess the correlation between(More)
Telemedicine is important technology for the health care. As the development of computer hardware, network environment is developing rapidly. The wireless internet access using mobile phone is natural in modern society. Hospital system is changing to digital environment. So compatible system is required using modern technologies between hospital and(More)
role in the era of molecular medicine. Optical imaging, a rising star in the filed of molecular imaging, largely consists of fluorescent imaging and bioluminescent imaging. Molecular imaging analysis will allow us to observe the incipience and progression of the disease. In this paper, we suggest image processing methods and develop software for(More)
Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the combination of NIRF with magnetic resonance imaging (MRI) is a good(More)
We have prepared polymeric micelle-encapsulating quantum dots (QDots) for delivering the optically activatable protein Killer Red (KR) as a plasmid to cancer cells. QDots absorb light at a lower wavelength and emit light at a higher wavelength in the cell cytoplasm, activating the expressed KR. Once activated, KR triggers the generation of reactive oxygen(More)
OBJECTIVES In order to evaluate the effect of post-reconstruction Gaussian filtering on image quality and myocardial blood flow (MBF) measurement by dynamic N-13 ammonia positron emission tomography (PET), we compared various reconstruction and filtering methods with image characteristics. METHODS Dynamic PET images of three patients with coronary artery(More)
We developed methods to represent cardiac motility. Using an innovative model, we estimated several parameters of cardiac features. We implemented the parameterized super quadric model to visualize the motion of a left ventricle (LV) with OpenGL and Visual C++. We displayed myocardial wall thickening with a super-ellipsoidal model. The time frames in this(More)
Cardiac disorder is one of the important diseases. Three-dimensional visualization and motility analysis of heart are necessaries to diagnosis of cardiac disorder. Because it is an important that diagnosis of cardiac disorder considers changing of shape with the passage of time. The purpose of this paper is to create a standard model of left ventricle(More)
The purpose of this study was to investigate coronary endothelial dysfunction in young healthy smokers by measuring myocardial blood flow (MBF) using [(15)O]H(2)O-PET. The study population was 18 young male volunteers consisted of 9 smokers (age: 23.8+/-1.1yr) and 9 non-smokers (age: 25.0+/-2.5yr). The smokers had been smoking cigarettes for 6.6+/-2.5 pack(More)