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In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences
Significance Decline in NAD+ availability and abnormal NAD+/NADH redox state are tightly linked to age-related metabolic diseases and neurodegenerative disorders. To better understand the roles ofExpand
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  • Open Access
Large improvement of RF transmission efficiency and reception sensitivity for human in vivo31P MRS imaging using ultrahigh dielectric constant materials at 7T.
In vivo31P MRS provides a unique and important imaging tool for studying high-energy phosphate metabolism and bioenergetics noninvasively. However, compared to 1H MRS, 31P MRS with a relatively lowExpand
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Functional energetic responses and individual variance of the human brain revealed by quantitative imaging of adenosine triphosphate production rates
Cellular ATP energy metabolism and regulation are essential for brain function and health. Given the high ATP expenditure at resting-state, it is not yet clear how the human brain at working-stateExpand
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High-resolution imaging of distinct human corpus callosum microstructure and topography of structural connectivity to cortices at high field
Characterization of the microstructural properties and topography of the human corpus callosum (CC) is key to understanding interhemispheric neural communication and brain function. In this work, weExpand
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Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome.
BACKGROUND Restless legs syndrome (RLS) is a neurological disorder characterized by a strong urge to move the legs and has been shown in many studies with abnormally low brain iron. Iron deficiencyExpand
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Involvement of the central somatosensory system in restless legs syndrome
Objective To investigate morphologic changes in the somatosensory cortex and the thickness of the corpus callosum subdivisions that provide interhemispheric connections between the 2 somatosensoryExpand
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Interleaved 31P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single‐channel transmitter–receiver and dynamic B0 shimming
In vivo 31P magnetic resonance spectroscopy (MRS) provides a unique tool for the non‐invasive study of brain energy metabolism and mitochondrial function. The assessment of bioenergetic impairment inExpand
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Elevated ATP Synthase and Creatine Kinase Activities in Human Visual Cortex during Visual Stimulation : A 31 P NMR Magnetization Transfer Study at 7 T
Introduction: The cerebral adenosine triphosphate (ATP) metabolism is mainly controlled by ATP synthase (ATPase), and creatine kinase (CK) reaction is coupled with ATP production/utilization andExpand
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  • Open Access
Redox State in Healthy Human Brain
Introduction The basic function of the NAD (nicotinamide adenine dinucleotide) for human is to release energy from nutrients in our diet through conversion between NADH (reduced form) andExpand
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  • Open Access
Quantitative analysis of spatial averaging effect on chemical shift imaging SNR and noise coherence with k-space sampling schemes.
Spatial averaging of multiple voxels from high-resolution chemical shift imaging (hrCSI) is a common strategy for in vivo metabolic studies to achieve a better signal-to-noise ratio (SNR) for aExpand
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