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Increasing late diagnosis in HIV infection in South Korea: 2000-2007
BackgroundThe number of Koreans diagnosed with human immunodeficiency virus (HIV) infections is increasing annually; however, CD4+ T-cell counts at diagnosis have decreased. The purpose of theExpand
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Distinctive distribution of HPV16 E6 D25E and E7 N29S intratypic Asian variants in Korean commercial sex workers
The distribution of HPV16 sequence variations differs geographically and specific HPV16 E6 and E7 variants might carry a high risk for development of invasive cervical cancer and cervicalExpand
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Genital human papillomavirus genotyping by HPV oligonucleotide microarray in Korean commercial sex workers
Because of the diversity in human papillomavirus (HPV) distribution, according to the population and region, detailed investigations of HPV genotypes are important in designing more effective HPVExpand
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A Simple Mouse Model for the Study of Human Immunodeficiency Virus.
Humanized mouse models derived from immune-deficient mice have been the primary tool for studies of human infectious viruses, such as human immunodeficiency virus (HIV). However, the current protocolExpand
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Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.
BACKGROUND & AIMS Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypicExpand
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Novel histone deacetylase inhibitors CG05 and CG06 effectively reactivate latently infected HIV-1
Histone deacetylase plays an important role in HIV latency. Novel histone deacetylase inhibitors, CG05 and CG06, were evaluated for their roles in HIV latency using ACH2 cells. Both inhibitors wereExpand
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The CD28/HLA‐DR expressions on CD4+T but not CD8+T cells are significant predictors for progression to AIDS
To investigate the changes of CD28 and HLA‐DR molecules on CD4+ and CD8+ T cells during HIV infection, we classified 130 HIV‐infected Koreans into four groups by the CD4 level as follows: group IExpand
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Genome-wide analysis of histone modifications in latently HIV-1 infected T cells
Objectives:The transcriptional silencing of HIV type 1 (HIV-1) provirus in latently infected cells is a major hurdle on the pathway to HIV-1 elimination. The epigenetic mechanisms established byExpand
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Impaired IL-2 expression in latent HIV-1 infection.
Regarding the T cell function in HIV-1 infection, activation of T cells is enhanced in acutely HIV-1-infected T cells upon stimuli. However, T cell immune responses underlying the activation of TExpand
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NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter
BackgroundHuman immunodeficiency virus-1 (HIV-1) Tat protein plays an essential role in HIV gene transcription from the HIV-1 long terminal repeat (LTR) and replication. Transcriptional activity ofExpand
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