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Insertional mutagenesis of Magnaporthe oryzae led to the identification of MCK1, a pathogenicity gene predicted to encode mitogen-activated protein kinase kinase kinase (MAPKKK) homologous to BCK1 in Saccharomyces cerevisiae. Targeted disruption of MCK1 resulted in the fungus undergoing autolysis and showing hypersensitivity to cell-wall-degrading enzyme.(More)
Agrobacterium tumefaciens-mediated transformation (ATMT) has become a prevalent tool for functional genomics of fungi, but our understanding of T-DNA integration into the fungal genome remains limited relative to that in plants. Using a model plant-pathogenic fungus, Magnaporthe oryzae, here we report the most comprehensive analysis of T-DNA integration(More)
Rapid translation of genome sequences into meaningful biological information hinges on the integration of multiple experimental and informatics methods into a cohesive platform. Despite the explosion in the number of genome sequences available, such a platform does not exist for filamentous fungi. Here we present the development and application of a(More)
Junhyun Jeon1, Sook-Young Park1,5, Myoung-Hwan Chi1, Jaehyuk Choi1, Jongsun Park1, Hee-Sool Rho1, Soonok Kim1, Jaeduk Goh1, Sungyong Yoo1, Jinhee Choi1, Ju-Young Park1, Mihwa Yi1, Seonyoung Yang1, Min-Jung Kwon1, Seong-Sook Han2, Byeong Ryun Kim2, Chang Hyun Khang3, Bongsoo Park1,5, Se-Eun Lim1, Kyongyong Jung1, Sunghyung Kong1, Maruthachalam Karunakaran1,(More)
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