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To estimate the accuracy of regional cerebral oxygen saturation (rSO(2)) in predicting postoperative cognitive dysfunction (POCD) for patients undergoing total hip arthroplasty, 46 patients aged more than 50years old were enrolled. We measured the patients' cognitive function by using a battery of six neuropsychological tests before surgery and then 7days(More)
OBJECTIVE Xenon provides neuroprotection in multiple animal models; however, little is known about the other noble gases. The aim of the current study was to compare xenon, argon, and helium neuroprotection in a neonatal asphyxia model in rats. DESIGN Randomized controlled trial. SETTING Laboratory. SUBJECTS Seven-day-old postnatal Sprague-Dawley(More)
BACKGROUND Perinatal hypoxia-ischemia causes significant morbidity and mortality. Xenon and sevoflurane may be used as inhalational analgesics for labor. Therefore, the authors investigated the potential application of these agents independently and in combination to attenuate perinatal injury. METHODS Oxygen-glucose deprivation injury was induced in pure(More)
OBJECTIVE The aims of this study were to investigate the effects of carbon-dioxide (CO(2)) insufflation on hemodynamic and respiratory function during laparoscopic inguinal hernioplasty and to evaluate the safety of transabdominal preperitoneal hernia repair (TAPP) and extraperitoneal hernia repair (TEP). MATERIALS AND METHODS Forty patients with inguinal(More)
BACKGROUND Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane is a commonly used anesthetic in children. Tau phosphorylation contributes to cognitive dysfunction. The authors therefore assessed the effects of sevoflurane on Tau phosphorylation and the underlying mechanisms in(More)
This study was conducted to investigate the effects of clonidine on bilateral pain behaviors and inflammatory responses in neuropathic pain induced by partial sciatic nerve ligation (PSNL), and to better understand whether the antinociception of clonidine was related to α(2)-adrenoceptor mechanisms. Rats were divided randomly into five groups:(More)
OBJECTIVE The aim of this study was to compare the anesthetic outcomes of elderly and younger patients perioperatively, and to evaluate the safety of this procedure in elderly. METHODS A total of 25 patients undergoing elective laparoscopic colorectal surgery were enrolled in this study prospectively. Ten patients were more than or equal to 70 years(More)
BACKGROUND Good postoperative recovery is increasingly recognized as an important outcome after surgery. The authors created a new Post-operative Quality Recovery Scale (PQRS) that tracks multiple domains of recovery from immediate to long-term time periods in patients of varying ages, languages, and cultures. METHODS The parameters of importance to both(More)
The contralateral allodynia to an injury has been described both in humans and various models of neuropathic and inflammatory pain in rats. In this article, the occurrence of mirror-image pain (MIP) in human beings and animals were reviewed and the possible mechanism of MIP reported was summarized. Last, according to the literature published, we raise some(More)
Alzheimer’s disease (AD) is the most common form of dementia. At the present time, however, AD still lacks effective treatments. Our recent studies showed that chronic treatment with anesthetic propofol attenuated brain caspase-3 activation and improved cognitive function in aged mice. Accumulation of β-amyloid protein (Aβ) is a major component of the(More)