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Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells.

• Pinar Kanlikilicer, Mohammed H. Rashed, +13 authors Gabriel López-Berestein
• Cancer research
• 2016

Cancer cells actively promote their tumorigenic behavior by reprogramming gene expression. Loading intraluminal vesicles with specific miRNAs and releasing them into the tumor microenvironment as… (More)

Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer.

• Vianey González-Villasana, Enrique Fuentes-Mattei, +15 authors Gabriel López-Berestein
• Clinical cancer research : an official journal of…
• 2015

PURPOSE Zoledronic acid is being increasingly recognized for its antitumor properties, but the underlying functions are not well understood. In this study, we hypothesized that zoledronic acid… (More)

Therapeutic Targeting of AXL Receptor Tyrosine Kinase Inhibits Tumor Growth and Intraperitoneal Metastasis in Ovarian Cancer Models

• Pinar Kanlikilicer, Bulent Ozpolat, +18 authors Gabriel López-Berestein
• Molecular therapy. Nucleic acids
• 2017

Despite substantial improvements in the treatment strategies, ovarian cancer is still the most lethal gynecological malignancy. Identification of drug treatable therapeutic targets and their safe and… (More)

Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs

• Mohammed H. Rashed, Pinar Kanlikilicer, +15 authors Gabriel Lopez Berestein
• Oncotarget
• 2017

Exosomes have emerged as important mediators of diverse biological functions including tumor suppression, tumor progression, invasion, immune escape and cell-to-cell communication, through the… (More)

Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery.

• Haifa Shen, Cristian Rodriguez-Aguayo, +18 authors Gabriel López-Berestein
• Clinical cancer research : an official journal of…
• 2013

PURPOSE RNA interference has the potential to specifically knockdown the expression of target genes and thereby transform cancer therapy. However, lack of effective delivery of siRNA has dramatically… (More)

The ZNF304-integrin axis protects against anoikis in cancer.

• Burcu Aslan, Paloma del C Monroig, +27 authors Gabriel López-Berestein
• Nature communications
• 2015

Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to target this process are currently available. Here, an integrative computational analysis of the Cancer Genome Atlas… (More)

Cancer Therapy : Preclinical Enhancing Chemotherapy Response with Sustained EphA 2 Silencing Using Multistage Vector Delivery

• Haifa Shen, Cristian Rodriguez-Aguayo, +18 authors Gabriel López-Berestein
• 2013

Purpose: RNA interference has the potential to specifically knockdown the expression of target genes and thereby transform cancer therapy. However, lack of effective delivery of siRNA has… (More)

MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase

• Recep Bayraktar, Martin Felix Pichler, +10 authors Bulent Ozpolat
• Oncotarget
• 2017

Triple negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by the absence of defined molecular targets, including estrogen receptor (ER), progesterone receptor (PR),… (More)

Chitosan Nanoparticles for miRNA Delivery.

• Merve Denizli, Burcu Aslan, +4 authors Anil Sood
• Methods in molecular biology
• 2017

RNA interference techniques represent a promising strategy for therapeutic applications. In addition to small interfering RNA-based approaches, which have been widely studied and translated into… (More)

Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer

• Pinar Kanlikilicer, Recep Bayraktar, +17 authors Gabriel López-Berestein
• EBioMedicine
• 2018

BACKGROUND Circulating miRNAs are known to play important roles in intercellular communication. However, the effects of exosomal miRNAs on cells are not fully understood. METHODS To investigate the… (More)

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