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Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.
TLDR
Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. Expand
Simultaneous determination of fourteen compounds of Hedyotis diffusa Willd extract in rats by UHPLC–MS/MS method: Application to pharmacokinetics and tissue distribution study
TLDR
The results provide useful information for improving the pharmacokinetics and biodistribution of fourteen bioactive ingredients of Hedyotis diffusa Willd extract in SD rats, supporting additional clinical application and Chinese herbal medicine safety evaluations. Expand
In vitro effect of a synthesized sulfonamido-based gallate on articular chondrocyte metabolism.
TLDR
A sulfonamido-based gallate, namely N-[4,6-dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-3,4,5-trihydroxy-benzamide (EJTC), is synthesized and investigated its effects on rabbit articular chondrocytes through an examination of its specific effects on cell proliferation, morphology, viability, GAG synthesis, and cartilage-specific gene expression. Expand
Synthesis, Biological Evaluation, and Docking Studies of a Novel Sulfonamido-Based Gallate as Pro-Chondrogenic Agent for the Treatment of Cartilage
TLDR
A novel sulfonamido-based gallate synthesized by bonding sulfonamide with GA was able to reverse the effects induced by Interleukin-1 (IL-1) stimulation, and it also had a great effect on chondro-protection via promoting cell proliferation and maintaining the phenotype of articular chONDrocytes. Expand
Comparison of two exploratory data analysis methods for classification of Phyllanthus chemical fingerprint: unsupervised vs. supervised pattern recognition technologies
TLDR
This study is the first holistic comparison of supervised and unsupervised pattern recognition technologies in the TCM chemical fingerprinting and showed advantages in sample classification and data mining, respectively. Expand
Chondro-Protective and Antiarthritic Effects of Sulfonamido-Based Gallate-ZXHA-TC in Vitro and in Vivo.
TLDR
ZXHA-TC may be developed as a potential therapeutic agent for OA through the suppression of the PI3K/AKT pathway or MAPK cascades, leading to NF-κB inactivation. Expand
A novel synthesized sulfonamido-based gallic acid--LDQN-C: effects on chondrocytes growth and phenotype maintenance.
TLDR
Results showed that LDQN-C could enhance secretion and synthesis of cartilage extracellular matrix (ECM) by up-regulating expression levels of aggrecan, collagen II and Sox9 genes compared to the GA treated group and control group and might provide a basis for the development of a novel agent for the treatment of articular cartilage defect. Expand
A Novel Synthesized Sulfonamido-Based Gallate—JEZ-C as Potential Therapeutic Agents for Osteoarthritis
TLDR
JEZ-C is revealed as a promising novel agent in the treatment of chondral and osteochondral lesions and can also exert chondro-protective effects by promoting cell proliferation and maintaining the phenotype of articular chONDrocytes, as evidenced by improved cell growth and enhanced synthesis of cartilage specific markers. Expand
Two new coumarins from the bark of Streblus indicus (Bur.) Corner
TLDR
Two new coumarins isolated from the bark of Streblus indicus exhibited moderate antimicrobial activity in vitro against Staphylococcus aureus strain with the MIC values of 62.5 and 125.0 μg/mL, respectively. Expand
Antimicrobial lignans derived from the roots of Streblus asper
Abstract Four new lignans, (7′ R ,8′ S )-4,4'-Dimethoxy-strebluslignanol ( 1 ), 3'-Hydroxy-isostrebluslignaldehyde ( 2 ), 3,3'-Methylene-bis(4-hydroxybenzaldehyde) ( 3 ), andExpand
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