Budhayash Gautam

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Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged as a nosocomial pathogen to the community which commonly causes skin and soft-tissue infections (SSTIs). This strain (MW2) has now become resistant to the most of the beta-lactam antibiotics; therefore it is the urgent need to identify the novel drug targets.(More)
Trichomonas vaginalis causes the trichomoniasis, in women and urethritis and prostate cancer in men. Its genome draft published by TIGR in 2007 presents many unusual genomic and biochemical features like, exceptionally large genome size, the presence of hydrogenosome, gene duplication, lateral gene transfer mechanism and the presence of miRNA. To understand(More)
AmpC is a group I, class C -lactamase present in most Enterobacteriaceae and in Pseudomonas aeruginosa and other nonfermenting gram-negative bacilli. The β-lactam class of antibiotics is one of the most important structural classes of antibacterial compounds and act by inhibiting the bacterial D ,D - transpeptidases that are responsible for the final step(More)
Toxoplasma gondii is an obligate intracellular Apicomplexan parasite that can infect a wide range of warmblooded animals including humans. This pathogen is one of the most common in humans due to many contributing factors that include: (1) its complex life cycle allows it to be transmitted both sexually via felid fecal matter and asexually via carnivorism.(More)
The root-knot nematode, Meloidogyne incognita causes significant damage to various economically important crops. Infection is associated with secretion of effector proteins into host cytoplasm and interference with host innate immunity. To combat this infection, the identification and functional annotations of Excretory/Secretory (ES) proteins serve as a(More)
In the present study, comparative genome analysis of Hepatitis B and C is done. The similarity and conservation of sequences were analyzed at the genome level by In silico approaches. The study revealed that both the sequences have identical conservation at the sequence level with each other. Both the genomes contain same numbers of the genes and sizes of(More)
The emergence of multidrug-resistant strain of community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) strain has highlighted the urgent need for the alternative and effective therapeutic approach to combat the menace of this nosocomial pathogen. In the present work novel potential therapeutic drug targets have been identified through the(More)
Non-small cell lung cancer today has several reported testimonies of aberrant promoter hypermethylation of tumor suppressing genes. In this study, a group of five genes (CDKN2A, APC, MGMT, DAPK and RASSF1) have been evaluated, using epigenetic tools and techniques to investigate their frequency of hypermethylation, prediction of CpG islands and expected(More)
Determination of the native geometry of the enzymes and ligand complexes is a key step in the process of structure-based drug designing. Enzymes and ligands show flexibility in structural behavior as they come in contact with each other. When ligand binds with active site of the enzyme, in the presence of cofactor some structural changes are expected to(More)
In our presented research, we made an attempt to predict the 3D model for cysteine synthase (A2GMG5_TRIVA) using homology-modeling approaches. To investigate deeper into the predicted structure, we further performed a molecular dynamics simulation for 10 ns and calculated several supporting analysis for structural properties such as RMSF, radius of(More)