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Tracking heavy water (D2O) incorporation for identifying and sorting active microbial cells
A new technique that allows fast and nondestructive activity measurements of microbial communities on a single-cell level in complex samples using stable isotope probing with heavy water (D2O) combined with Raman microspectroscopy is developed. Expand
Lifestyle and Horizontal Gene Transfer-Mediated Evolution of Mucispirillum schaedleri, a Core Member of the Murine Gut Microbiota
The lifestyle of the gut bacterium Mucispirillum schaedleri, which is associated with inflammation in widely used mouse models, is found to have specialized systems to handle oxidative stress during inflammation, suggesting that M. schaederi undergoes intimate interactions with its host and may play a role in inflammation. Expand
Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis.
This study causally linked Mucispirillum schaedleri, currently the sole known representative of Deferribacteres present in the mammalian microbiota, to host protection against S. Tm colitis, and establishes M. schaederi, a core member of the murine gut microbiota, as a key antagonist of S.Tm virulence in the gut. Expand
Metaproteomic Survey of Six Aquatic Habitats: Discovering the Identities of Microbial Populations Active in Biogeochemical Cycling
By documenting both processes expressed in situ and the identity of host cells, metaproteomics tested several existing hypotheses about ecophysiological processes and provided fodder for new ones. Expand
Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation†
It is suggested that, while cellular uptake and cytotoxicity strongly correlate with lipophilicity, cytot toxicity under hypoxia compared to non-hypoxic conditions and antitumor activity of platinum(iv) prodrugs are dependent on their rate of reduction. Expand
Bacterial nutrient foraging in a mouse model of enteral nutrient deprivation: insight into the gut origin of sepsis.
Gavage of small bowel effluent from TPN mice into germ-free, fed mice resulted in a trend toward the proinflammatory TPN phenotype with loss of epithelial barrier function. Expand
Dynamic secondary ion mass spectrometry imaging of microbial populations utilizing C-labelled substrates in pure culture and in soil.
We demonstrate that dynamic secondary ion mass spectrometry (SIMS)-based ion microscopy can provide a means of measuring (13)C assimilation into individual bacterial cells grown on (13)C-labelledExpand
Environmental and Intestinal Phylum Firmicutes Bacteria Metabolize the Plant Sugar Sulfoquinovose via a 6-Deoxy-6-sulfofructose Transaldolase Pathway
A third biochemical pathway for primary SQ degradation in an aerobic Bacillus aryabhattai strain is revealed, highlighting a potential importance of metabolism of green-diet SQ by gut microbial communities to, ultimately, hydrogen sulfide. Expand
Community dynamics and functional characteristics of naphthalene‐degrading populations in contaminated surface sediments and hypoxic/anoxic groundwater
Earlier research on the biogeochemical factors affecting natural attenuation in coal-tar contaminated groundwater, at South Glens Falls, NY, revealed the importance of anaerobic metabolism andExpand
In situ expression of nitrite-dependent anaerobic methane oxidation proteins by Candidatus Methylomirabilis oxyfera co-occurring with expressed anammox proteins in a contaminated aquifer.
Environmental metaproteomics revealed a microbial population, closely related to Ca. Expand