Bryon D. Johnson

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Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells.

Gang Cheng, Jacek Zielonka, +9 authors Balaraman Kalyanaraman
Cancer research
2016

Metformin (Met) is an approved antidiabetic drug currently being explored for repurposing in cancer treatment based on recent evidence of its apparent chemopreventive properties. Met is weakly… (More)

Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.

Tyce J. Kearl, Weiqing Jing, Jill A. Gershan, Bryon D. Johnson
Journal of immunology
2013

Early phase clinical trials targeting the programmed death receptor-1/ligand-1 (PD-1/PD-L1) pathway to overcome tumor-mediated immunosuppression have reported promising results for a variety of… (More)

Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L (4-1BBL) is superior to CD28, and CD137L expressed on neuroblastoma expands CD8 tumour-reactive…

Xiaocai Yan, Bryon D. Johnson, Rimas J. Orentas
Immunology
2004

The ability to expand tumour-infiltrating lymphocytes in vitro has been greatly enhanced by the use of antigen-independent mechanisms of immune cell costimulation. We have produced human, using the… (More)

Cloning and expression of Aspergillus fumigatus allergen Asp f 16 mediating both humoral and cell-mediated immunity in allergic bronchopulmonary aspergillosis (ABPA).

Banani Banerjee, Viswanath P. Kurup, Paul A. Greenberger, Bryon D. Johnson, Jordan N. Fink
Clinical and experimental allergy : journal of…
2001

BACKGROUND Aspergillus fumigatus, a ubiquitous fungus, is responsible for a number of lung disorders in atopic and non-atopic individuals. Standardized, pure, and relevant allergens are desirable for… (More)

Delayed infusion of immunocompetent donor cells after bone marrow transplantation breaks graft-host tolerance allows for persistent antileukemic reactivity without severe graft-versus-host disease.

The development of graft-host tolerance after bone marrow transplantation (BMT) is crucial to avoid the problems of graft-versus-host disease (GVHD) and graft rejection. GVHD can be eliminated by… (More)

Graft-versus-leukemia and graft-versus-host reactions after donor lymphocyte infusion are initiated by host-type antigen-presenting cells and regulated by regulatory T cells in early and long-term…

Guliang Xia, Robert L. Truitt, Bryon D. Johnson
Biology of blood and marrow transplantation…
2006

Regulatory T (T(reg)) cells and host antigen-presenting cells (APCs) have been implicated in graft-versus-host disease (GVHD) and the graft-versus-leukemia (GVL) effect after donor lymphocyte… (More)

Suppression of anti-cancer immunity by regulatory T cells: back to the future.

Rimas J. Orentas, M. Eric Kohler, Bryon D. Johnson
Seminars in cancer biology
2006

Suppressor/regulatory T cells were first shown to have an impact on cancer progression in experimental tumor models during the 1970s. However, the lack of specific markers hindered mechanistic… (More)

Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A.

Qizhen Shi, David A. Wilcox, +5 authors Robert R. Montgomery
Journal of thrombosis and haemostasis : JTH
2007

BACKGROUND Previous studies from our laboratory have demonstrated that lineage-targeted synthesis of factor VIII (FVIII) under the direction of the platelet-specific integrin alphaIIb gene promoter… (More)

Immune response modulation by curcumin in a latex allergy model

Viswanath P. Kurup, Christy S. Barrios, Raghavan Raju, Bryon D. Johnson, Michael B. Levy, Jordan N. Fink
Clinical and molecular allergy : CMA
2007

BACKGROUND There has been a worldwide increase in allergy and asthma over the last few decades, particularly in industrially developed nations. This resulted in a renewed interest to understand the… (More)

CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance.

Michael D Rosenblum, E. B. Olasz, +6 authors Robert L. Truitt
Blood
2004

During apoptotic cell death, biochemical processes modify self-proteins and create potential autoantigens. To maintain self-tolerance in the face of natural cell turnover, the immune system must… (More)

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