Brychan C. Thomas

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Forty-nine children who had undergone treatment with cyclophosphamide and total body irradiation before bone marrow transplantation were investigated for impaired endocrine function. Twenty-six patients received single fraction total body irradiation as a dose of 9-10 Gy, whereas 23 patients received fractionated total body irradiation as a total dose of(More)
We describe 6 (4F, 2M) prepubertal children with moderate asthma diagnosed at a mean age of 2.8 years. All patients were treated with inhaled corticosteroids in a dose of between 300 and 800 mcg of beclomethasone dipropionate (becotide) daily, given either as an aerosol or rotahaler. Mean height velocity SDS decreased from -0.8 (range +0.5 to -2.0) to -3.2(More)
It is maintained that processes such as lean construction can arguably reduce costs within the construction process. These costs primarily arise due to a lack of harmonisation between contracting parties. Historically, this relationship has been transactional in nature, with both parties seeking to secure value added at minimal cost. Despite this fact,(More)
Ten girls with early puberty secondary to cranial irradiation as a part of the treatment for acute lymphoblastic leukaemia (ALL) were treated with either gonadotropin-releasing hormone analogue (GnRHa) and human growth hormone (GH) (8 girls) or with GnRHa alone (2 girls). After 4 years of treatment, height SDS for bone age was improved in the group who(More)
When unlimited supplies of biosynthetic human growth hormone (hGH) became available in the late 1980s, the envisaged potential of its therapeutic applications was enormous in that it was hoped that perhaps most short children would be able to be made taller. However, this seems to have been far too simplistic a view and certainly in those children with(More)
Contrary to the assertion that the entrepreneur is instrumental in small business growth, the process of growth cannot be construed as automatic. Accordingly there is a need to examine the relationships between the personal characteristics, experience, knowledge, skills and motivations of the entrepreneur in determining the strategic direction of subsequent(More)
It is recognised that Small and Medium-sized Enterprises (SMEs) need to adapt and change to remain competitive in the rapidly changing business environment of the 21 st Century. As with many other industries this is evident in the Agri-food industry in Wales where Agri-food SMEs can attain a competitive advantage through the use of Information and(More)
Heritage is the key to the success of the tourism industry in Wales. Tourism itself is one of the largest and most important industries in the Principality contributing £2.0 billion in spending from overnight and day visitors, 7% to GDP and 10% of jobs to the economy (100,000 jobs). Following a period of substantial growth, during the 1980s and 1990s, it(More)