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Fibrates, such as fenofibrate, are peroxisome proliferator-activated receptor-α (PPARα) agonists and have been used for several decades as hypolipidemic agents in the clinic. However, contradictory observations exist on the role of fibrates in host response to acute inflammation, with unclear mechanisms. The role of PPARα in colitis was assessed using(More)
30 liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass 31 spectrometry. Abstract 34 Fibrates, such as fenofibrate, are peroxisome proliferator-activated receptor α (PPARα) agonists, 35 and have been used for several decades as hypolipidemic agents in the clinic. However, 36 contradictory observations exist on the role(More)
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