Bryce X. Bredell

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Fibrates, such as fenofibrate, are peroxisome proliferator-activated receptor-α (PPARα) agonists and have been used for several decades as hypolipidemic agents in the clinic. However, contradictory observations exist on the role of fibrates in host response to acute inflammation, with unclear mechanisms. The role of PPARα in colitis was assessed using(More)
Several distinct congenital disorders can lead to tissue-iron overload with anemia. Repeated blood transfusions are one of the major causes of iron overload in several of these disorders, including β-thalassemia major, which is characterized by a defective β-globin gene. In this state, hyperabsorption of iron is also observed and can significantly(More)
34 Fibrates, such as fenofibrate, are peroxisome proliferator-activated receptor α (PPARα) agonists, 35 and have been used for several decades as hypolipidemic agents in the clinic. However, 36 contradictory observations exist on the role of fibrates in host response to acute inflammation, 37 with unclear mechanisms. The role of PPARα in colitis was(More)
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